Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3169918..3170549 Replicon chromosome
Accession NZ_CP045798
Organism Thermoanaerosceptrum fracticalcis strain DRI-13

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag BR63_RS16150 Protein ID WP_034426056.1
Coordinates 3170148..3170549 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A7G6E6F5
Locus tag BR63_RS16145 Protein ID WP_034426058.1
Coordinates 3169918..3170145 (+) Length 76 a.a.

Genomic Context

BR63_RS16120BR63_RS16125BR63_RS16130BR63_RS16135BR63_RS16140BR63_RS16145BR63_RS16150BR63_RS16170BR63_RS16175BR63_RS16115BR63_RS16155BR63_RS16160BR63_RS16165
Location: 3165598..3165909 (312 bp)
Type: Others
Protein ID: WP_051966310.1
Location: 3166133..3167370 (1238 bp)
Type: Others
Protein ID: Protein_3152
Location: 3168034..3168669 (636 bp)
Type: Others
Protein ID: Protein_3153
Location: 3168719..3169024 (306 bp)
Type: Others
Protein ID: Protein_3154
Location: 3169377..3169541 (165 bp)
Type: Others
Protein ID: WP_153802206.1
Location: 3169918..3170145 (228 bp)
Type: Antitoxin
Protein ID: WP_034426058.1
Location: 3170148..3170549 (402 bp)
Type: Toxin
Protein ID: WP_034426056.1
Location: 3174470..3174571 (102 bp)
Type: Others
Protein ID: Protein_3161
Location: 3175059..3175334 (276 bp)
Type: Others
Protein ID: WP_034424294.1
Location: 3164963..3165280 (318 bp)
Type: Others
Protein ID: WP_034425938.1
Location: 3170788..3171480 (693 bp)
Type: Others
Protein ID: WP_034426054.1
Location: 3171687..3172019 (333 bp)
Type: Others
Protein ID: WP_207724815.1
Location: 3172787..3174050 (1264 bp)
Type: Others
Protein ID: Protein_3160
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BR63_RS161153164963..3165280-318WP_034425938.1hypothetical protein-
BR63_RS161203165598..3165909+312WP_051966310.1transposase-
BR63_RS161253166133..3167370+1238Protein_3152IS110 family transposase-
BR63_RS161303168034..3168669+636Protein_3153transposase-
BR63_RS161353168719..3169024+306Protein_3154transposase-
BR63_RS161403169377..3169541+165WP_153802206.1hypothetical protein-
BR63_RS161453169918..3170145+228WP_034426058.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
BR63_RS161503170148..3170549+402WP_034426056.1type II toxin-antitoxin system VapC family toxinToxin
BR63_RS161553170788..3171480-693WP_034426054.1HNH endonuclease-
BR63_RS161603171687..3172019-333WP_207724815.1nucleotide-binding protein-
BR63_RS161653172787..3174050-1264Protein_3160IS3 family transposase-
BR63_RS161703174470..3174571+102Protein_3161hypothetical protein-
BR63_RS161753175059..3175334+276WP_034424294.1AbrB/MazE/SpoVT family DNA-binding domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(8-46)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15057.75 Da        Isoelectric Point: 9.3651

>T142601 WP_034426056.1 NZ_CP045798:3170148-3170549 [Thermoanaerosceptrum fracticalcis]
MRYMLDTNICIYIIKKKPVQVFQIFNALKVGDVCISSITLAELQYGVYKSQFPERNKLALVNFLAPITILPFSDRASVLY
GHIRAGLEKRGQIIGAYDLMIAAHALSEDLILVTNNTKEFSRIPNLPLKNWAE

Download         Length: 402 bp

>T142601 NZ_CP060748:2590793-2590900 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTAGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8769.00 Da        Isoelectric Point: 4.8146

>AT142601 WP_034426058.1 NZ_CP045798:3169918-3170145 [Thermoanaerosceptrum fracticalcis]
MDIAKIFFNGRSQAVRLPKEYRLEGSEVYVKKIDDVVLLIPKDSAWKTLESSLNYFSDDFMAERNQPEIEKREGL

Download         Length: 228 bp

>AT142601 NZ_CP060748:c2590737-2590681 [Escherichia coli]
TCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7G6E6F5

References