Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 1924683..1925313 Replicon chromosome
Accession NZ_CP045798
Organism Thermoanaerosceptrum fracticalcis strain DRI-13

Toxin (Protein)


Gene name pemK Uniprot ID A0A7G6E3D5
Locus tag BR63_RS09900 Protein ID WP_034421612.1
Coordinates 1924683..1925036 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag BR63_RS09905 Protein ID WP_034421614.1
Coordinates 1925038..1925313 (-) Length 92 a.a.

Genomic Context

BR63_RS09885BR63_RS09890BR63_RS09895BR63_RS09900BR63_RS09905BR63_RS09910BR63_RS09915BR63_RS09920BR63_RS09925
Location: 1920224..1921051 (828 bp)
Type: Others
Protein ID: WP_034421607.1
Location: 1921261..1923411 (2151 bp)
Type: Others
Protein ID: WP_034421609.1
Location: 1923425..1924429 (1005 bp)
Type: Others
Protein ID: WP_034421610.1
Location: 1924683..1925036 (354 bp)
Type: Toxin
Protein ID: WP_034421612.1
Location: 1925038..1925313 (276 bp)
Type: Antitoxin
Protein ID: WP_034421614.1
Location: 1925408..1926538 (1131 bp)
Type: Others
Protein ID: WP_034421655.1
Location: 1926729..1928279 (1551 bp)
Type: Others
Protein ID: WP_034421615.1
Location: 1928267..1928653 (387 bp)
Type: Others
Protein ID: WP_034421617.1
Location: 1928763..1930100 (1338 bp)
Type: Others
Protein ID: WP_034421618.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
BR63_RS098851920224..1921051-828WP_034421607.1hypothetical protein-
BR63_RS098901921261..1923411-2151WP_034421609.1RNA-binding transcriptional accessory protein-
BR63_RS098951923425..1924429-1005WP_034421610.1asparaginase-
BR63_RS099001924683..1925036-354WP_034421612.1type II toxin-antitoxin system PemK/MazF family toxinToxin
BR63_RS099051925038..1925313-276WP_034421614.1ribbon-helix-helix protein, CopG familyAntitoxin
BR63_RS099101925408..1926538-1131WP_034421655.1alanine racemase-
BR63_RS099151926729..1928279-1551WP_034421615.1bifunctional ADP-dependent NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase-
BR63_RS099201928267..1928653-387WP_034421617.1holo-ACP synthase-
BR63_RS099251928763..1930100-1338WP_034421618.1phosphoglucosamine mutase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(7-43)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 12728.67 Da        Isoelectric Point: 5.1528

>T142600 WP_034421612.1 NZ_CP045798:c1925036-1924683 [Thermoanaerosceptrum fracticalcis]
MVTVKRGDIFYADLSPVVGSEQGGTRPVLIIQNDIGNQYSPTTIVAAITSQLDKAKLPTHVEISCESCGLTKDSVILTEQ
IRTIDKRRLQEKVSSLDEVTMGKVSRALEISLGLVEL

Download         Length: 354 bp

>T142600 NZ_CP060748:c2430484-2430308 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10835.65 Da        Isoelectric Point: 4.9231

>AT142600 WP_034421614.1 NZ_CP045798:c1925313-1925038 [Thermoanaerosceptrum fracticalcis]
VSETKRIMICLPADLLEEVDGIMTIEKKNRSEFIREAMRFYLAETKRKNLREQMRRGYLEMAQINLTLAQEAFYSELEVD
ILYQNKLVECL

Download         Length: 276 bp

>AT142600 NZ_CP060748:c2430262-2429846 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7G6E3D5

Antitoxin

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Source
ID
Structure
No matching records found

References