Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/Phd(antitoxin) |
| Location | 1983955..1984502 | Replicon | chromosome |
| Accession | NZ_CP045794 | ||
| Organism | Vibrio parahaemolyticus 10329 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A249W5B6 |
| Locus tag | GH799_RS10145 | Protein ID | WP_005500333.1 |
| Coordinates | 1984200..1984502 (+) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | U3A269 |
| Locus tag | GH799_RS10140 | Protein ID | WP_005448240.1 |
| Coordinates | 1983955..1984212 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GH799_RS10065 | 1979284..1979376 | + | 93 | WP_193268598.1 | DUF3265 domain-containing protein | - |
| GH799_RS10070 | 1979421..1979705 | + | 285 | WP_005500325.1 | nucleotide pyrophosphohydrolase | - |
| GH799_RS10075 | 1979713..1979823 | + | 111 | WP_082798391.1 | DUF3265 domain-containing protein | - |
| GH799_RS10080 | 1979850..1980122 | + | 273 | WP_005462157.1 | nicotinamide mononucleotide transporter | - |
| GH799_RS10085 | 1980154..1980243 | + | 90 | WP_079748734.1 | DUF3265 domain-containing protein | - |
| GH799_RS10090 | 1980274..1980570 | + | 297 | WP_005500327.1 | hypothetical protein | - |
| GH799_RS10095 | 1980510..1980677 | + | 168 | WP_086027883.1 | DUF3265 domain-containing protein | - |
| GH799_RS10100 | 1980707..1981087 | + | 381 | WP_005487927.1 | TonB family protein | - |
| GH799_RS10105 | 1981094..1981204 | + | 111 | WP_079861117.1 | DUF3265 domain-containing protein | - |
| GH799_RS10110 | 1981214..1981723 | + | 510 | WP_005500328.1 | hypothetical protein | - |
| GH799_RS10115 | 1981738..1981830 | + | 93 | WP_005500330.1 | DUF3265 domain-containing protein | - |
| GH799_RS10120 | 1981856..1982293 | + | 438 | WP_005500331.1 | GIY-YIG nuclease family protein | - |
| GH799_RS10125 | 1983000..1983197 | + | 198 | WP_005500332.1 | hypothetical protein | - |
| GH799_RS10135 | 1983805..1983873 | + | 69 | WP_079748735.1 | DUF3265 domain-containing protein | - |
| GH799_RS10140 | 1983955..1984212 | + | 258 | WP_005448240.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GH799_RS10145 | 1984200..1984502 | + | 303 | WP_005500333.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GH799_RS10150 | 1984541..1984630 | + | 90 | WP_072828861.1 | DUF3265 domain-containing protein | - |
| GH799_RS10155 | 1984678..1985046 | + | 369 | WP_005500334.1 | VOC family protein | - |
| GH799_RS10160 | 1985203..1986042 | + | 840 | WP_005500335.1 | hypothetical protein | - |
| GH799_RS10165 | 1986191..1986544 | + | 354 | WP_005500336.1 | glyoxalase/bleomycin resistance/dioxygenase family protein | - |
| GH799_RS25255 | 1986505..1986639 | + | 135 | WP_161612893.1 | DUF3265 domain-containing protein | - |
| GH799_RS10175 | 1986668..1986946 | - | 279 | WP_005500338.1 | type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family | - |
| GH799_RS10180 | 1986943..1987227 | - | 285 | WP_005398409.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| GH799_RS10185 | 1987494..1987784 | + | 291 | WP_005500341.1 | YkgJ family cysteine cluster protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1901578..1990819 | 89241 | |
| - | inside | Integron | - | - | 1902102..1990138 | 88036 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11682.65 Da Isoelectric Point: 6.9806
>T142597 WP_005500333.1 NZ_CP045794:1984200-1984502 [Vibrio parahaemolyticus 10329]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPKSGRIPPELEHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPKSGRIPPELEHLSYREVVVNPCRIFYKQDGDKV
FILFVMRAERDLRKFLLSKQ
Download Length: 303 bp
>T142597 NZ_CP060748:1897432-1897686 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9606.10 Da Isoelectric Point: 6.7269
>AT142597 WP_005448240.1 NZ_CP045794:1983955-1984212 [Vibrio parahaemolyticus 10329]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK
Download Length: 258 bp
>AT142597 NZ_CP060748:1897184-1897435 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A249W5B6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A432DGX8 |