Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) FicTA/Fic(toxin)
Location 16388..17306 Replicon plasmid p2CFSAN032805
Accession NZ_CP045792
Organism Campylobacter coli strain CFSAN032805

Toxin (Protein)


Gene name Fic Uniprot ID A0A3Z8EYW1
Locus tag GH773_RS08655 Protein ID WP_002790624.1
Coordinates 16623..17306 (+) Length 228 a.a.

Antitoxin (Protein)


Gene name Fti Uniprot ID A0A0Q2TTN4
Locus tag GH773_RS08650 Protein ID WP_002804094.1
Coordinates 16388..16630 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH773_RS09140 11389..11529 + 141 WP_002779802.1 hypothetical protein -
GH773_RS08635 11534..13747 + 2214 WP_052778217.1 DUF1738 domain-containing protein -
GH773_RS08640 13744..15567 + 1824 WP_057031751.1 type IV secretory system conjugative DNA transfer family protein -
GH773_RS08645 15578..16297 + 720 WP_057031750.1 conjugal transfer protein TraL -
GH773_RS08650 16388..16630 + 243 WP_002804094.1 hypothetical protein Antitoxin
GH773_RS08655 16623..17306 + 684 WP_002790624.1 Fic family protein Toxin
GH773_RS08660 17311..17778 + 468 WP_057031749.1 signal peptidase I -
GH773_RS08665 17843..18238 + 396 WP_004294083.1 conjugal transfer protein TraM -
GH773_RS08670 18330..19016 + 687 WP_002791558.1 AAA family ATPase -
GH773_RS08675 19019..19243 + 225 WP_002790621.1 hypothetical protein -
GH773_RS08680 19484..21640 - 2157 WP_002838514.1 relaxase/mobilization nuclease domain-containing protein -
GH773_RS08685 21603..21986 - 384 WP_002797386.1 DNA transfer protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..25046 25046


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(60-169)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 228 a.a.        Molecular weight: 25802.76 Da        Isoelectric Point: 10.0206

>T142594 WP_002790624.1 NZ_CP045792:16623-17306 [Campylobacter coli]
MIDKVLKFLDDGIPKNDFDRQLLASNLVGATNLIELNKKERIITLQAAKKLELNPIKGNFDYQHLKDIHKALFKDVYTWA
GKDRMEVGLHGNFGKYAPNGTITNFVPGKDLNVTAQQIFTWLKEDNYLTNSKDLNDFAKNLAEFARNLNALHPFREGNGR
TQRIFLNELAKNAGYKLDLNLIPKDKMIMASVEASQLKLGKLEAIIKTNLKSFRQNLDLEQNKGISL

Download         Length: 684 bp

>T142594 NZ_CP060748:944490-944897 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9452.68 Da        Isoelectric Point: 4.3535

>AT142594 WP_002804094.1 NZ_CP045792:16388-16630 [Campylobacter coli]
MQKQYPEVHSLEESLAILKKYKDDLTKEQYEQNKSIICGFAIENMFANEEDIINLIKVDKQEKTPDEIIAEYKKEWGVND

Download         Length: 243 bp

>AT142594 NZ_CP060748:944243-944509 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z8EYW1

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q2TTN4

References