Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 2230158..2230789 Replicon chromosome
Accession NZ_CP045784
Organism Shigella dysenteriae strain CFSAN029786

Toxin (Protein)


Gene name hicA Uniprot ID U9Y2A7
Locus tag GH770_RS11265 Protein ID WP_001259385.1
Coordinates 2230158..2230433 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A3P6LLN4
Locus tag GH770_RS11270 Protein ID WP_000593559.1
Coordinates 2230430..2230789 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH770_RS11250 (2225162) 2225162..2226229 + 1068 WP_000361465.1 HlyD family secretion protein -
GH770_RS11255 (2226226) 2226226..2228961 + 2736 WP_000149136.1 ribosome-associated ATPase/putative transporter RbbA -
GH770_RS11260 (2228961) 2228961..2230085 + 1125 WP_001216257.1 ABC transporter permease -
GH770_RS11265 (2230158) 2230158..2230433 + 276 WP_001259385.1 type II toxin-antitoxin system HicA family toxin Toxin
GH770_RS11270 (2230430) 2230430..2230789 + 360 WP_000593559.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GH770_RS11275 (2230909) 2230909..2231310 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
GH770_RS11280 (2231316) 2231316..2232122 - 807 WP_000173710.1 nickel import ATP-binding protein NikE -
GH770_RS11285 (2232119) 2232119..2232883 - 765 WP_001136222.1 nickel import ATP-binding protein NikD -
GH770_RS11290 (2232883) 2232883..2233716 - 834 WP_001008964.1 nickel ABC transporter permease subunit NikC -
GH770_RS11295 (2233713) 2233713..2234657 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10199.94 Da        Isoelectric Point: 10.7076

>T142573 WP_001259385.1 NZ_CP045784:2230158-2230433 [Shigella dysenteriae]
MRTKVQALRKKQKNTLDQIFKTPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP

Download         Length: 276 bp

>T142573 NZ_CP060737:c2818448-2818345 [Enterobacter roggenkampii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13373.27 Da        Isoelectric Point: 4.8838

>AT142573 WP_000593559.1 NZ_CP045784:2230430-2230789 [Shigella dysenteriae]
MIKLKTPNTMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLLEYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp

>AT142573 NZ_CP060737:2818340-2818483 [Enterobacter roggenkampii]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4P7TTW8

Antitoxin

Source ID Structure
AlphaFold DB A0A3P6LLN4

References