Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 260838..261633 | Replicon | chromosome |
| Accession | NZ_CP045784 | ||
| Organism | Shigella dysenteriae strain CFSAN029786 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | Q93EZ7 |
| Locus tag | GH770_RS01325 | Protein ID | WP_000854917.1 |
| Coordinates | 260838..261212 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | D2ACA1 |
| Locus tag | GH770_RS01330 | Protein ID | WP_001280958.1 |
| Coordinates | 261259..261633 (-) | Length | 125 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GH770_RS01285 (256159) | 256159..256863 | + | 705 | WP_001241678.1 | leucyl/phenylalanyl-tRNA--protein transferase | - |
| GH770_RS01290 (257148) | 257148..257366 | + | 219 | WP_001040187.1 | translation initiation factor IF-1 | - |
| GH770_RS01300 (257857) | 257857..258138 | - | 282 | Protein_254 | DUF4942 domain-containing protein | - |
| GH770_RS01305 (258420) | 258420..259424 | - | 1005 | WP_001179707.1 | IS110-like element ISSfl8 family transposase | - |
| GH770_RS01310 (259496) | 259496..260056 | - | 561 | Protein_256 | DUF4942 domain-containing protein | - |
| GH770_RS01315 (260141) | 260141..260338 | - | 198 | WP_000839282.1 | DUF957 domain-containing protein | - |
| GH770_RS01320 (260350) | 260350..260841 | - | 492 | WP_000976828.1 | DUF5983 family protein | - |
| GH770_RS01325 (260838) | 260838..261212 | - | 375 | WP_000854917.1 | TA system toxin CbtA family protein | Toxin |
| GH770_RS01330 (261259) | 261259..261633 | - | 375 | WP_001280958.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| GH770_RS01335 (261796) | 261796..262017 | - | 222 | WP_001220314.1 | DUF987 domain-containing protein | - |
| GH770_RS01340 (262080) | 262080..262556 | - | 477 | WP_005011624.1 | RadC family protein | - |
| GH770_RS01345 (262572) | 262572..263045 | - | 474 | WP_005011597.1 | antirestriction protein | - |
| GH770_RS01350 (263387) | 263387..264208 | - | 822 | WP_001234584.1 | DUF932 domain-containing protein | - |
| GH770_RS01355 (264308) | 264308..264481 | - | 174 | WP_000088744.1 | DUF905 family protein | - |
| GH770_RS26035 (264601) | 264601..264864 | - | 264 | WP_000466628.1 | DNA polymerase III subunit gamma/tau | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | tet(B) / catA1 / blaOXA-1 / ant(3'')-Ia | clbQ | 258420..333029 | 74609 | |
| - | flank | IS/Tn | - | - | 258420..259424 | 1004 | |
| - | flank | IS/Tn | - | - | 265047..265550 | 503 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14145.22 Da Isoelectric Point: 7.7761
>T142567 WP_000854917.1 NZ_CP045784:c261212-260838 [Shigella dysenteriae]
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
MKTLSDTHVREVSRCPSPVTIWQTLLIRLLDQHYGLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T142567 NZ_CP060737:529012-529296 [Enterobacter roggenkampii]
ATGACTTATGAACTGGAATTTGACCCGAGGGCGTTAAAGGAGTGGAGCAAGCTGGGGGATACGGTCAAAAACCAGTTTAA
GAAGAAACTTGCCGGGGTATTGGCAAATCCCCGGGTCGAATCGGCCCGCCTGCATAATCTGCCTGATTGCTACAAAATCA
AACTCAAGGCGTCTGGCTATCGCCTGGTTTATCAGGTTCAGGACAGCGTTATAACGGTATTTGTTATCGCCGTTGGGAAA
AGAGAGAAATCAGCCGCTTATCACGACGCAAATAAACGGCTTTAG
ATGACTTATGAACTGGAATTTGACCCGAGGGCGTTAAAGGAGTGGAGCAAGCTGGGGGATACGGTCAAAAACCAGTTTAA
GAAGAAACTTGCCGGGGTATTGGCAAATCCCCGGGTCGAATCGGCCCGCCTGCATAATCTGCCTGATTGCTACAAAATCA
AACTCAAGGCGTCTGGCTATCGCCTGGTTTATCAGGTTCAGGACAGCGTTATAACGGTATTTGTTATCGCCGTTGGGAAA
AGAGAGAAATCAGCCGCTTATCACGACGCAAATAAACGGCTTTAG
Antitoxin
Download Length: 125 a.a. Molecular weight: 13793.62 Da Isoelectric Point: 6.4651
>AT142567 WP_001280958.1 NZ_CP045784:c261633-261259 [Shigella dysenteriae]
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
VSDKLSGITHPDDNHDRPWWGLPCTVRPCFGARLVQEGNRLYYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPAPATTS
Download Length: 375 bp
>AT142567 NZ_CP060737:528780-529022 [Enterobacter roggenkampii]
ATGGCCACGCTAAACGTCCGTCTGGATGACAAACTTAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATTACCCC
AACGGAAGCGGTGCGATTGCTGTTTCAGTACGTTGCTGAAACGGGGCGCATGCCGGTGAAAACGGTCACCATTAGCGACA
GCGAAGATGCGCTGATACAGACAGTCCGGGAGCGACTGGCTAATCCGCAAAAGGGAATAAAGGTTAGTCTGGATGACTTA
TGA
ATGGCCACGCTAAACGTCCGTCTGGATGACAAACTTAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATTACCCC
AACGGAAGCGGTGCGATTGCTGTTTCAGTACGTTGCTGAAACGGGGCGCATGCCGGTGAAAACGGTCACCATTAGCGACA
GCGAAGATGCGCTGATACAGACAGTCCGGGAGCGACTGGCTAATCCGCAAAAGGGAATAAAGGTTAGTCTGGATGACTTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q93EZ7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K4PAV2 |