Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2175528..2176185 Replicon chromosome
Accession NZ_CP045783
Organism Klebsiella variicola strain LEMB11

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GFC07_RS10370 Protein ID WP_002916310.1
Coordinates 2175528..2175938 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GFC07_RS10375 Protein ID WP_002916312.1
Coordinates 2175919..2176185 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFC07_RS10350 2171528..2173261 - 1734 WP_008806424.1 single-stranded-DNA-specific exonuclease RecJ -
GFC07_RS10355 2173267..2173980 - 714 WP_008806425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GFC07_RS10360 2174003..2174899 - 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
GFC07_RS10365 2175000..2175521 + 522 WP_008806427.1 flavodoxin FldB -
GFC07_RS10370 2175528..2175938 - 411 WP_002916310.1 protein YgfX Toxin
GFC07_RS10375 2175919..2176185 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GFC07_RS10380 2176431..2177414 + 984 WP_008806428.1 tRNA-modifying protein YgfZ -
GFC07_RS10385 2177570..2178229 - 660 WP_008806429.1 hemolysin III family protein -
GFC07_RS10390 2178393..2178704 - 312 WP_008806430.1 N(4)-acetylcytidine aminohydrolase -
GFC07_RS10395 2178755..2179483 + 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
GFC07_RS10400 2179603..2181036 + 1434 WP_012967244.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T142561 WP_002916310.1 NZ_CP045783:c2175938-2175528 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T142561 NZ_CP060733:c2784610-2784507 [Enterobacter roggenkampii]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT142561 WP_002916312.1 NZ_CP045783:c2176185-2175919 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT142561 NZ_CP060733:2784502-2784645 [Enterobacter roggenkampii]
CAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTCGCCTTGCCTTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References