Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 275777..277365 | Replicon | chromosome |
Accession | NZ_CP045783 | ||
Organism | Klebsiella variicola strain LEMB11 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | A0A1F2MCM0 |
Locus tag | GFC07_RS01335 | Protein ID | WP_008804919.1 |
Coordinates | 276043..277365 (+) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A1F2MCN9 |
Locus tag | GFC07_RS01330 | Protein ID | WP_008804920.1 |
Coordinates | 275777..276043 (+) | Length | 89 a.a. |
Genomic Context
Location: 270927..271850 (924 bp)
Type: Others
Protein ID: WP_008804925.1
Type: Others
Protein ID: WP_008804925.1
Location: 273331..274710 (1380 bp)
Type: Others
Protein ID: WP_008804923.1
Type: Others
Protein ID: WP_008804923.1
Location: 274688..275188 (501 bp)
Type: Others
Protein ID: WP_008804922.1
Type: Others
Protein ID: WP_008804922.1
Location: 275185..275511 (327 bp)
Type: Others
Protein ID: WP_008804921.1
Type: Others
Protein ID: WP_008804921.1
Location: 275777..276043 (267 bp)
Type: Antitoxin
Protein ID: WP_008804920.1
Type: Antitoxin
Protein ID: WP_008804920.1
Location: 276043..277365 (1323 bp)
Type: Toxin
Protein ID: WP_008804919.1
Type: Toxin
Protein ID: WP_008804919.1
Location: 271831..272985 (1155 bp)
Type: Others
Protein ID: WP_032735567.1
Type: Others
Protein ID: WP_032735567.1
Location: 277382..278674 (1293 bp)
Type: Others
Protein ID: WP_012968243.1
Type: Others
Protein ID: WP_012968243.1
Location: 278807..279811 (1005 bp)
Type: Others
Protein ID: WP_032730346.1
Type: Others
Protein ID: WP_032730346.1
Location: 279799..282300 (2502 bp)
Type: Others
Protein ID: WP_022066169.1
Type: Others
Protein ID: WP_022066169.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GFC07_RS01305 | 270927..271850 | + | 924 | WP_008804925.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
GFC07_RS01310 | 271831..272985 | - | 1155 | WP_032735567.1 | FAD-dependent urate hydroxylase HpxO | - |
GFC07_RS01315 | 273331..274710 | + | 1380 | WP_008804923.1 | purine permease | - |
GFC07_RS01320 | 274688..275188 | + | 501 | WP_008804922.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
GFC07_RS01325 | 275185..275511 | + | 327 | WP_008804921.1 | hydroxyisourate hydrolase | - |
GFC07_RS01330 | 275777..276043 | + | 267 | WP_008804920.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
GFC07_RS01335 | 276043..277365 | + | 1323 | WP_008804919.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
GFC07_RS01340 | 277382..278674 | - | 1293 | WP_012968243.1 | glycoside hydrolase family 10 protein | - |
GFC07_RS01345 | 278807..279811 | - | 1005 | WP_032730346.1 | type 1 fimbrial protein | - |
GFC07_RS01350 | 279799..282300 | - | 2502 | WP_022066169.1 | fimbrial biogenesis outer membrane usher protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 48911.26 Da Isoelectric Point: 7.9109
>T142551 WP_008804919.1 NZ_CP045783:276043-277365 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T142551 NZ_CP060726:c4600484-4599165 [Providencia rettgeri]
ATGGCGACTTTGCATGTATACATGAATGGTTACTTAGTTGGGGATTTGATTCGTTCAAGTACTGGTGCTCACCAATTTAC
TTATAATAGTCACTGGTTGGAAACATCAGGTGCTCGACCTATTTCTTTATCAATGCCACTTAGGCACCAAGAATATCGAG
GAGACGAAGTTTATAATTTTTTTGATAATCTCCTACCGGACAATATTGAGATACGGAATCGAATTGTTAGTCGTTATCAA
GCGGATTCAAATCAACCTTTCGATTTATTATCTAAGATTGGCCAGGATAGTGTGGGGGCTTTACAACTCATTCTAGATGG
GCAAAGAGTCAGTAATATCAGAAAAATTGAATATAAACCCTTATCTAATAAGCAACTAGAAAAAATATTAACAGGGTATA
AAGTGAATGCTCCTTTAGGCATGATTGAAGATGAAGATGACTTTAGGATCTCACTTGCGGGCGCTCAAGAGAAAACCGCA
TTACTCTATTTAGATGGGCATTGGTGCTTACCTCAGAATGCGACTCCAACTACCCATATTATTAAACTTCCCATTGGTAA
AATAGAAAGCCATTCTTATTCGATAGATATGTCGGATAGTGTAGAAAATGAATATTTATGTTTATTGATAGCAAAAGAGT
TTGGCCTAGATGTGCCTCGTAGCTTTATTTTAAATGTAGGTGAAATAAAGGCGTTAGCGGTTGAACGTTTTGACCGTAAA
TATTCTTCTGATTCCTCGTGGATTATGCGTTTACCACAAGAAGATTTTTGTCAAACATTGAATATTTCACCAGCAAGAAA
ATATCAAAATCATGGTGGACCGGGTATTTCTGAAATTATGAATTACTTATTGGGTTCAATAAATGCAGAGAAAGATAGAT
ATCAGTTTATGAAGAGCCAAGTTTTGTTCTGGCTACTTGCAGCGACGGATGGTCATGCTAAAAATTTTTCATTATTTATT
GAACCTGAAGGCCGTTATCAGTTAACACCTTTTTACGATATTTTGTCCATGTATCCTAGTTATGGGGGGAGGGGAATTAA
CCCTAGAGATGCCAAATTGGCTATGGGACTGAAGGGAACAAAGGGGATGAAATACAATATAGAGCAAATTTTCCCAAGAC
ATTTTTTTTCAACGGCCAAAGCCGTTGGATTTGATCGTGCTGAGATGGAAAAAATCTTAATTGAATTTGGTGAGCAAATG
GAAAGTGTTCTTAAGAAAGTGAGAGAACAATTACCCACAGATTTCCCTGAGCATATCGCAGACTCAATTCTATCCGGATT
ACATCACAAAGCAGCGAGATTAAATAAAGGCTGGGACTAA
ATGGCGACTTTGCATGTATACATGAATGGTTACTTAGTTGGGGATTTGATTCGTTCAAGTACTGGTGCTCACCAATTTAC
TTATAATAGTCACTGGTTGGAAACATCAGGTGCTCGACCTATTTCTTTATCAATGCCACTTAGGCACCAAGAATATCGAG
GAGACGAAGTTTATAATTTTTTTGATAATCTCCTACCGGACAATATTGAGATACGGAATCGAATTGTTAGTCGTTATCAA
GCGGATTCAAATCAACCTTTCGATTTATTATCTAAGATTGGCCAGGATAGTGTGGGGGCTTTACAACTCATTCTAGATGG
GCAAAGAGTCAGTAATATCAGAAAAATTGAATATAAACCCTTATCTAATAAGCAACTAGAAAAAATATTAACAGGGTATA
AAGTGAATGCTCCTTTAGGCATGATTGAAGATGAAGATGACTTTAGGATCTCACTTGCGGGCGCTCAAGAGAAAACCGCA
TTACTCTATTTAGATGGGCATTGGTGCTTACCTCAGAATGCGACTCCAACTACCCATATTATTAAACTTCCCATTGGTAA
AATAGAAAGCCATTCTTATTCGATAGATATGTCGGATAGTGTAGAAAATGAATATTTATGTTTATTGATAGCAAAAGAGT
TTGGCCTAGATGTGCCTCGTAGCTTTATTTTAAATGTAGGTGAAATAAAGGCGTTAGCGGTTGAACGTTTTGACCGTAAA
TATTCTTCTGATTCCTCGTGGATTATGCGTTTACCACAAGAAGATTTTTGTCAAACATTGAATATTTCACCAGCAAGAAA
ATATCAAAATCATGGTGGACCGGGTATTTCTGAAATTATGAATTACTTATTGGGTTCAATAAATGCAGAGAAAGATAGAT
ATCAGTTTATGAAGAGCCAAGTTTTGTTCTGGCTACTTGCAGCGACGGATGGTCATGCTAAAAATTTTTCATTATTTATT
GAACCTGAAGGCCGTTATCAGTTAACACCTTTTTACGATATTTTGTCCATGTATCCTAGTTATGGGGGGAGGGGAATTAA
CCCTAGAGATGCCAAATTGGCTATGGGACTGAAGGGAACAAAGGGGATGAAATACAATATAGAGCAAATTTTCCCAAGAC
ATTTTTTTTCAACGGCCAAAGCCGTTGGATTTGATCGTGCTGAGATGGAAAAAATCTTAATTGAATTTGGTGAGCAAATG
GAAAGTGTTCTTAAGAAAGTGAGAGAACAATTACCCACAGATTTCCCTGAGCATATCGCAGACTCAATTCTATCCGGATT
ACATCACAAAGCAGCGAGATTAAATAAAGGCTGGGACTAA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9936.30 Da Isoelectric Point: 8.5912
>AT142551 WP_008804920.1 NZ_CP045783:275777-276043 [Klebsiella variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW
Download Length: 267 bp
>AT142551 NZ_CP060726:c4600741-4600484 [Providencia rettgeri]
ATGAAAGTGACGAATACCCGACAACTTAGTGCTTATATGAAGGATGTCAGAGAGACGAAAAAGTTATCTCAAAGCAAAGT
CGCTAGTAAAGTAGGTATTCGGCAAGATACTGTTTCTAGCTTTGAACTCTCTCCTGACTCTACCAAATTAGAAACCTTTT
TTAAGATTTTATCTGCCCTCAATTTAGAACTCGATATTAAACCGCGAAATGAAAGCGGCTCATCAAATTCAGACTCCGGA
TGGAAGGAGGAGTGGTGA
ATGAAAGTGACGAATACCCGACAACTTAGTGCTTATATGAAGGATGTCAGAGAGACGAAAAAGTTATCTCAAAGCAAAGT
CGCTAGTAAAGTAGGTATTCGGCAAGATACTGTTTCTAGCTTTGAACTCTCTCCTGACTCTACCAAATTAGAAACCTTTT
TTAAGATTTTATCTGCCCTCAATTTAGAACTCGATATTAAACCGCGAAATGAAAGCGGCTCATCAAATTCAGACTCCGGA
TGGAAGGAGGAGTGGTGA
Structures
Toxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1F2MCM0 |
Antitoxin
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Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1F2MCN9 |