Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 275777..277365 Replicon chromosome
Accession NZ_CP045783
Organism Klebsiella variicola strain LEMB11

Toxin (Protein)


Gene name hipA Uniprot ID A0A1F2MCM0
Locus tag GFC07_RS01335 Protein ID WP_008804919.1
Coordinates 276043..277365 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MCN9
Locus tag GFC07_RS01330 Protein ID WP_008804920.1
Coordinates 275777..276043 (+) Length 89 a.a.

Genomic Context


GFC07_RS01305GFC07_RS01315GFC07_RS01320GFC07_RS01325GFC07_RS01330GFC07_RS01335GFC07_RS01310GFC07_RS01340GFC07_RS01345GFC07_RS01350
Location: 270927..271850 (924 bp)
Type: Others
Protein ID: WP_008804925.1
Location: 273331..274710 (1380 bp)
Type: Others
Protein ID: WP_008804923.1
Location: 274688..275188 (501 bp)
Type: Others
Protein ID: WP_008804922.1
Location: 275185..275511 (327 bp)
Type: Others
Protein ID: WP_008804921.1
Location: 275777..276043 (267 bp)
Type: Antitoxin
Protein ID: WP_008804920.1
Location: 276043..277365 (1323 bp)
Type: Toxin
Protein ID: WP_008804919.1
Location: 271831..272985 (1155 bp)
Type: Others
Protein ID: WP_032735567.1
Location: 277382..278674 (1293 bp)
Type: Others
Protein ID: WP_012968243.1
Location: 278807..279811 (1005 bp)
Type: Others
Protein ID: WP_032730346.1
Location: 279799..282300 (2502 bp)
Type: Others
Protein ID: WP_022066169.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GFC07_RS01305270927..271850+924WP_008804925.1LysR family hpxDE operon transcriptional regulator HpxR-
GFC07_RS01310271831..272985-1155WP_032735567.1FAD-dependent urate hydroxylase HpxO-
GFC07_RS01315273331..274710+1380WP_008804923.1purine permease-
GFC07_RS01320274688..275188+501WP_008804922.12-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase-
GFC07_RS01325275185..275511+327WP_008804921.1hydroxyisourate hydrolase-
GFC07_RS01330275777..276043+267WP_008804920.1type II toxin-antitoxin system antitoxin HipBAntitoxin
GFC07_RS01335276043..277365+1323WP_008804919.1type II toxin-antitoxin system HipA family toxinToxin
GFC07_RS01340277382..278674-1293WP_012968243.1glycoside hydrolase family 10 protein-
GFC07_RS01345278807..279811-1005WP_032730346.1type 1 fimbrial protein-
GFC07_RS01350279799..282300-2502WP_022066169.1fimbrial biogenesis outer membrane usher protein-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-103)

Antitoxin

(13-65)


Sequences


Toxin        


Download         Length: 441 a.a.        Molecular weight: 48911.26 Da        Isoelectric Point: 7.9109

>T142551 WP_008804919.1 NZ_CP045783:276043-277365 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T142551 NZ_CP060726:c4600484-4599165 [Providencia rettgeri]
ATGGCGACTTTGCATGTATACATGAATGGTTACTTAGTTGGGGATTTGATTCGTTCAAGTACTGGTGCTCACCAATTTAC
TTATAATAGTCACTGGTTGGAAACATCAGGTGCTCGACCTATTTCTTTATCAATGCCACTTAGGCACCAAGAATATCGAG
GAGACGAAGTTTATAATTTTTTTGATAATCTCCTACCGGACAATATTGAGATACGGAATCGAATTGTTAGTCGTTATCAA
GCGGATTCAAATCAACCTTTCGATTTATTATCTAAGATTGGCCAGGATAGTGTGGGGGCTTTACAACTCATTCTAGATGG
GCAAAGAGTCAGTAATATCAGAAAAATTGAATATAAACCCTTATCTAATAAGCAACTAGAAAAAATATTAACAGGGTATA
AAGTGAATGCTCCTTTAGGCATGATTGAAGATGAAGATGACTTTAGGATCTCACTTGCGGGCGCTCAAGAGAAAACCGCA
TTACTCTATTTAGATGGGCATTGGTGCTTACCTCAGAATGCGACTCCAACTACCCATATTATTAAACTTCCCATTGGTAA
AATAGAAAGCCATTCTTATTCGATAGATATGTCGGATAGTGTAGAAAATGAATATTTATGTTTATTGATAGCAAAAGAGT
TTGGCCTAGATGTGCCTCGTAGCTTTATTTTAAATGTAGGTGAAATAAAGGCGTTAGCGGTTGAACGTTTTGACCGTAAA
TATTCTTCTGATTCCTCGTGGATTATGCGTTTACCACAAGAAGATTTTTGTCAAACATTGAATATTTCACCAGCAAGAAA
ATATCAAAATCATGGTGGACCGGGTATTTCTGAAATTATGAATTACTTATTGGGTTCAATAAATGCAGAGAAAGATAGAT
ATCAGTTTATGAAGAGCCAAGTTTTGTTCTGGCTACTTGCAGCGACGGATGGTCATGCTAAAAATTTTTCATTATTTATT
GAACCTGAAGGCCGTTATCAGTTAACACCTTTTTACGATATTTTGTCCATGTATCCTAGTTATGGGGGGAGGGGAATTAA
CCCTAGAGATGCCAAATTGGCTATGGGACTGAAGGGAACAAAGGGGATGAAATACAATATAGAGCAAATTTTCCCAAGAC
ATTTTTTTTCAACGGCCAAAGCCGTTGGATTTGATCGTGCTGAGATGGAAAAAATCTTAATTGAATTTGGTGAGCAAATG
GAAAGTGTTCTTAAGAAAGTGAGAGAACAATTACCCACAGATTTCCCTGAGCATATCGCAGACTCAATTCTATCCGGATT
ACATCACAAAGCAGCGAGATTAAATAAAGGCTGGGACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.30 Da        Isoelectric Point: 8.5912

>AT142551 WP_008804920.1 NZ_CP045783:275777-276043 [Klebsiella variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT142551 NZ_CP060726:c4600741-4600484 [Providencia rettgeri]
ATGAAAGTGACGAATACCCGACAACTTAGTGCTTATATGAAGGATGTCAGAGAGACGAAAAAGTTATCTCAAAGCAAAGT
CGCTAGTAAAGTAGGTATTCGGCAAGATACTGTTTCTAGCTTTGAACTCTCTCCTGACTCTACCAAATTAGAAACCTTTT
TTAAGATTTTATCTGCCCTCAATTTAGAACTCGATATTAAACCGCGAAATGAAAGCGGCTCATCAAATTCAGACTCCGGA
TGGAAGGAGGAGTGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A1F2MCM0


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1F2MCN9

References