Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2402440..2403097 Replicon chromosome
Accession NZ_CP045782
Organism Klebsiella pneumoniae strain LEMB18

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GFB99_RS11620 Protein ID WP_002916310.1
Coordinates 2402440..2402850 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GFB99_RS11625 Protein ID WP_002916312.1
Coordinates 2402831..2403097 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFB99_RS11600 2398440..2400173 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
GFB99_RS11605 2400179..2400892 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GFB99_RS11610 2400915..2401811 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GFB99_RS11615 2401912..2402433 + 522 WP_004144730.1 flavodoxin FldB -
GFB99_RS11620 2402440..2402850 - 411 WP_002916310.1 protein YgfX Toxin
GFB99_RS11625 2402831..2403097 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GFB99_RS11630 2403343..2404326 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
GFB99_RS11635 2404477..2405136 - 660 WP_002916317.1 hemolysin III family protein -
GFB99_RS11640 2405300..2405611 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
GFB99_RS11645 2405661..2406389 + 729 WP_117053803.1 MurR/RpiR family transcriptional regulator -
GFB99_RS11650 2406508..2407941 + 1434 WP_040219565.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T142542 WP_002916310.1 NZ_CP045782:c2402850-2402440 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T142542 NZ_CP060726:c883603-883400 [Providencia rettgeri]
ATGACCAAATCTGATTATCTGATGCGTTTAAGAAAATGCACCACAATTGAAACACTTGAGCGTGTCATTGAAAAAAATAA
GTATGAATTATCTGATGATGAGCTAGAGCTATTCTATTCAGCAGCAGATCACCGCTTAGCTGAACTCACAATGAATAAGC
TTTATGATAAAATCCCAGCGTCTGTTTGGAAGTTTGTTAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT142542 WP_002916312.1 NZ_CP045782:c2403097-2402831 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT142542 NZ_CP060726:c884046-883678 [Providencia rettgeri]
ATGGATGAATACTCACCCAAAAGACATGATATAGCAGAACTAAAATACTTATGTAATAGTCTCAATAGAGACGCTATTTT
AAGCTTACAAAAAACAAATACACACTGGATTAATGATTTAAGCTCCCCGCAAAGCGCAGCCTTGAATGAACTCATTGAAC
ATATCGCTGCATTTGTATGGCGGTTTAAAATCAAATACCCAAAAGAAAATCTTGTTATATCACTTATCGAAGAATACCTC
GATGAGACCTATGATTTATTCGGCAGCCCAGTTATCACACTTAGTGAAATTATAGACTGGGAAGCAATGAATCACAGCCT
TGTCGCTGTGCTGGATGATGACCTAAAGTGCCTAACCAGCAAAACTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References