Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 3229297..3230272 Replicon chromosome
Accession NZ_CP045777
Organism Bacillus paranthracis strain CFSAN068816

Toxin (Protein)


Gene name spoIISA Uniprot ID B7HS47
Locus tag GH772_RS18230 Protein ID WP_002027714.1
Coordinates 3229535..3230272 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag GH772_RS18225 Protein ID WP_000588712.1
Coordinates 3229297..3229422 (-) Length 42 a.a.

Genomic Context

GH772_RS18210GH772_RS18245GH772_RS18195GH772_RS18200GH772_RS18205GH772_RS18215GH772_RS18220GH772_RS18225GH772_RS18230GH772_RS18235GH772_RS18240GH772_RS18250GH772_RS18255GH772_RS18260
Location: 3226984..3227355 (372 bp)
Type: Others
Protein ID: WP_000670600.1
Location: 3231955..3233640 (1686 bp)
Type: Others
Protein ID: WP_002027713.1
Location: 3224676..3225503 (828 bp)
Type: Others
Protein ID: WP_001060779.1
Location: 3225493..3226026 (534 bp)
Type: Others
Protein ID: WP_000438318.1
Location: 3226248..3226841 (594 bp)
Type: Others
Protein ID: WP_000265892.1
Location: 3227432..3228901 (1470 bp)
Type: Others
Protein ID: WP_000287521.1
Location: 3229045..3229221 (177 bp)
Type: Others
Protein ID: WP_000852618.1
Location: 3229297..3229422 (126 bp)
Type: Antitoxin
Protein ID: WP_000588712.1
Location: 3229535..3230272 (738 bp)
Type: Toxin
Protein ID: WP_002027714.1
Location: 3230461..3231198 (738 bp)
Type: Others
Protein ID: WP_000594123.1
Location: 3231366..3231848 (483 bp)
Type: Others
Protein ID: WP_000191904.1
Location: 3233762..3233854 (93 bp)
Type: Others
Protein ID: Protein_3284
Location: 3233960..3234367 (408 bp)
Type: Others
Protein ID: WP_000072484.1
Location: 3234487..3235197 (711 bp)
Type: Others
Protein ID: WP_000787481.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GH772_RS181953224676..3225503-828WP_001060779.1hypothetical protein-
GH772_RS182003225493..3226026-534WP_000438318.1sigma-70 family RNA polymerase sigma factor-
GH772_RS182053226248..3226841-594WP_000265892.1SGNH/GDSL hydrolase family protein-
GH772_RS182103226984..3227355+372WP_000670600.1DUF5065 family protein-
GH772_RS182153227432..3228901-1470WP_000287521.1beta-Ala-His dipeptidase-
GH772_RS182203229045..3229221-177WP_000852618.1hypothetical protein-
GH772_RS182253229297..3229422-126WP_000588712.1hypothetical proteinAntitoxin
GH772_RS182303229535..3230272-738WP_002027714.1type II toxin-antitoxin system SpoIISA family toxinToxin
GH772_RS182353230461..3231198-738WP_000594123.12,3-diphosphoglycerate-dependent phosphoglycerate mutase-
GH772_RS182403231366..3231848-483WP_000191904.1MarR family winged helix-turn-helix transcriptional regulator-
GH772_RS182453231955..3233640+1686WP_002027713.1alpha-keto acid decarboxylase family protein-
GH772_RS182503233762..3233854-93Protein_3284methyltransferase-
GH772_RS182553233960..3234367-408WP_000072484.1VOC family protein-
GH772_RS182603234487..3235197-711WP_000787481.1class I SAM-dependent methyltransferase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28415.15 Da        Isoelectric Point: 8.2672

>T142530 WP_002027714.1 NZ_CP045777:c3230272-3229535 [Bacillus paranthracis]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTSIIQNVNPVVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T142530 NZ_CP060714:c2661085-2660216 [Diaphorobacter ruginosibacter]
ATGTCTTCTTCGTCCTCTTCACCCGGCATCCAGGCGGCGATCGAGCGCATGGAGGCGGTCTTTCCGCAGAGGCTGGTCGC
GCTTGGTGCGCAGCGTCAGGTGGCGTGGCGCGAGGCGGGGGATGGCGAATCCGACTTTGCCTATGTCTGCCTGCACGGCA
TCAGCTCGTCCGCAGCGTCGTGGTTCGGCGTGGCCGAGCGCCTGCTGGCGAATGCGCGTGTTCTGGCTTGGGACGCTCCC
GGCTATGGCGAATCCACGCCACTTTCCGTGGATGCCCCGACCGATGCGGACTACGCGCGCGTGCTTGGCGAGTCGCTTGC
CGCGCTGGGCGTGCGTCGCTGCGTGCTGGTGGGGCATTCGCTCGGGTGTCTCGTGGCCGCGCGCTGGGCTTGCGATGCGT
CTGCCCTGCAGATCCAGATCCGGCAATTGGTGTTGATGAGCCCCGCGGGCGGCTATGGTGCGCCAGCGAAGGCGGAGCAG
AGGGCCAGGGTGATGTCCGGGCGCGTCGATGCGCTCAGGGATCAAGGTGTGTCCGGCATTGCTGCCGTGATCGACCAGCG
CCTGTGCGCACCCGGTGCGCCCGGGCCTGCGCGTGAGTGGGTGCGCTGGAACGCATCGCGCATGCGCGCCGGAGGCTACC
TGCAGGCCGTGCACCTGCTGTGCTCCGGTGATCTGGGGGAGGCATCGGGCCGCTTGACGATGCCGGTTCACGTATGGGTG
GGTACCGAGGACGTGGTGACCACTCCGGAAGCGAGTGAGGCCTGGGCCCGGAGACTGGGAGCGCAATACGTTACGCTTGC
GAAGGCTGGCCACGCCTGCGTTGTCGAACAACCGGAGAAGATCGCGCAGATGTTGGCCCATTTGAGCTGA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT142530 WP_000588712.1 NZ_CP045777:c3229422-3229297 [Bacillus paranthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT142530 NZ_CP060714:c2660198-2659392 [Diaphorobacter ruginosibacter]
ATGAGTGACACCACTTCTTCGCCCGACACCGATCGTGATACCGACCGCTACACCGTTCCTGCCCTGGAGCGGGGGCTGCG
CCTGATGAACTGCTTCAGTCCCACGCAGCCCGTCTGGAGCGCTCCTGATCTGGCGCGTGAGCTGGAATTGCCGCGTTCCA
CGGTGTTCCGGATGCTGACCACCCTCGAGAACATGGGCTACCTGCAGCGTTCTGGTACCGAGTACCGCCTGGGGCTTGCC
GTGCTGCGGCTGGGGTACGACTACCTCTCCAGCCAGCCGCTGGCGAACCTGGCGCAACCGGTGATGCAGGCGCTGCACGA
GCAACTGGGCTTCACCTGCAACCTGGCATTGCTGGACGGGACGTCGATTGTCTATGTGGCGCGCGTGGGCCACAGCAGCG
AGTTCCAGAGCGCGGTGCGGGTCGGCTCGCGCCTTCCGGCCCATGCGACGGTGCTGGGGCGCGTGCTGCTGCAGGACATG
ACGGCCCCGCAATTGCGCAAGCTCTATGGCGGCAACGAGCTGCCGATGTTCACGCCGAGCACGCCGCGCACGGTGGACGA
CTTGCTGGCGTTGATCGCCCAGGATGTCGAGCGCGGCTACGCGGAGGGCGAGGGCTTCTATGAATCCGGCGTGTCGGGCA
TCGCGGCCCCGGTGCGCGGTGGCGACGGAAAGATCGTGGCGGGCATCGGCATGGTGGTGCCGTTTGCCGAAGTGGGGCGT
GCGCGTTCGGGCCATTGGGTGGACCAGGTCGTGCACGCTACCCGGGAACTGTCGGGATATCTGCGCGCGCAGCATCCCAT
GTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5M9H7T3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A366GQT1

References