Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 3229297..3230272 Replicon chromosome
Accession NZ_CP045777
Organism Bacillus paranthracis strain CFSAN068816

Toxin (Protein)


Gene name spoIISA Uniprot ID B7HS47
Locus tag GH772_RS18230 Protein ID WP_002027714.1
Coordinates 3229535..3230272 (-) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID R8HWP4
Locus tag GH772_RS18225 Protein ID WP_000588712.1
Coordinates 3229297..3229422 (-) Length 42 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH772_RS18195 3224676..3225503 - 828 WP_001060779.1 hypothetical protein -
GH772_RS18200 3225493..3226026 - 534 WP_000438318.1 sigma-70 family RNA polymerase sigma factor -
GH772_RS18205 3226248..3226841 - 594 WP_000265892.1 SGNH/GDSL hydrolase family protein -
GH772_RS18210 3226984..3227355 + 372 WP_000670600.1 DUF5065 family protein -
GH772_RS18215 3227432..3228901 - 1470 WP_000287521.1 beta-Ala-His dipeptidase -
GH772_RS18220 3229045..3229221 - 177 WP_000852618.1 hypothetical protein -
GH772_RS18225 3229297..3229422 - 126 WP_000588712.1 hypothetical protein Antitoxin
GH772_RS18230 3229535..3230272 - 738 WP_002027714.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
GH772_RS18235 3230461..3231198 - 738 WP_000594123.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
GH772_RS18240 3231366..3231848 - 483 WP_000191904.1 MarR family winged helix-turn-helix transcriptional regulator -
GH772_RS18245 3231955..3233640 + 1686 WP_002027713.1 alpha-keto acid decarboxylase family protein -
GH772_RS18250 3233762..3233854 - 93 Protein_3284 methyltransferase -
GH772_RS18255 3233960..3234367 - 408 WP_000072484.1 VOC family protein -
GH772_RS18260 3234487..3235197 - 711 WP_000787481.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(9-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28415.15 Da        Isoelectric Point: 8.2672

>T142530 WP_002027714.1 NZ_CP045777:c3230272-3229535 [Bacillus paranthracis]
VISNIRIGLFILAIVFLILVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTSIIQNVNPVVFGTMEWHTEEEYTKSLNVFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSTIIPLEYIEQLNEQRAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T142530 NZ_CP060714:c2661085-2660216 [Diaphorobacter ruginosibacter]
ATGTCTTCTTCGTCCTCTTCACCCGGCATCCAGGCGGCGATCGAGCGCATGGAGGCGGTCTTTCCGCAGAGGCTGGTCGC
GCTTGGTGCGCAGCGTCAGGTGGCGTGGCGCGAGGCGGGGGATGGCGAATCCGACTTTGCCTATGTCTGCCTGCACGGCA
TCAGCTCGTCCGCAGCGTCGTGGTTCGGCGTGGCCGAGCGCCTGCTGGCGAATGCGCGTGTTCTGGCTTGGGACGCTCCC
GGCTATGGCGAATCCACGCCACTTTCCGTGGATGCCCCGACCGATGCGGACTACGCGCGCGTGCTTGGCGAGTCGCTTGC
CGCGCTGGGCGTGCGTCGCTGCGTGCTGGTGGGGCATTCGCTCGGGTGTCTCGTGGCCGCGCGCTGGGCTTGCGATGCGT
CTGCCCTGCAGATCCAGATCCGGCAATTGGTGTTGATGAGCCCCGCGGGCGGCTATGGTGCGCCAGCGAAGGCGGAGCAG
AGGGCCAGGGTGATGTCCGGGCGCGTCGATGCGCTCAGGGATCAAGGTGTGTCCGGCATTGCTGCCGTGATCGACCAGCG
CCTGTGCGCACCCGGTGCGCCCGGGCCTGCGCGTGAGTGGGTGCGCTGGAACGCATCGCGCATGCGCGCCGGAGGCTACC
TGCAGGCCGTGCACCTGCTGTGCTCCGGTGATCTGGGGGAGGCATCGGGCCGCTTGACGATGCCGGTTCACGTATGGGTG
GGTACCGAGGACGTGGTGACCACTCCGGAAGCGAGTGAGGCCTGGGCCCGGAGACTGGGAGCGCAATACGTTACGCTTGC
GAAGGCTGGCCACGCCTGCGTTGTCGAACAACCGGAGAAGATCGCGCAGATGTTGGCCCATTTGAGCTGA

Antitoxin


Download         Length: 42 a.a.        Molecular weight: 4938.34 Da        Isoelectric Point: 3.9150

>AT142530 WP_000588712.1 NZ_CP045777:c3229422-3229297 [Bacillus paranthracis]
VIKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRK

Download         Length: 126 bp

>AT142530 NZ_CP060714:c2660198-2659392 [Diaphorobacter ruginosibacter]
ATGAGTGACACCACTTCTTCGCCCGACACCGATCGTGATACCGACCGCTACACCGTTCCTGCCCTGGAGCGGGGGCTGCG
CCTGATGAACTGCTTCAGTCCCACGCAGCCCGTCTGGAGCGCTCCTGATCTGGCGCGTGAGCTGGAATTGCCGCGTTCCA
CGGTGTTCCGGATGCTGACCACCCTCGAGAACATGGGCTACCTGCAGCGTTCTGGTACCGAGTACCGCCTGGGGCTTGCC
GTGCTGCGGCTGGGGTACGACTACCTCTCCAGCCAGCCGCTGGCGAACCTGGCGCAACCGGTGATGCAGGCGCTGCACGA
GCAACTGGGCTTCACCTGCAACCTGGCATTGCTGGACGGGACGTCGATTGTCTATGTGGCGCGCGTGGGCCACAGCAGCG
AGTTCCAGAGCGCGGTGCGGGTCGGCTCGCGCCTTCCGGCCCATGCGACGGTGCTGGGGCGCGTGCTGCTGCAGGACATG
ACGGCCCCGCAATTGCGCAAGCTCTATGGCGGCAACGAGCTGCCGATGTTCACGCCGAGCACGCCGCGCACGGTGGACGA
CTTGCTGGCGTTGATCGCCCAGGATGTCGAGCGCGGCTACGCGGAGGGCGAGGGCTTCTATGAATCCGGCGTGTCGGGCA
TCGCGGCCCCGGTGCGCGGTGGCGACGGAAAGATCGTGGCGGGCATCGGCATGGTGGTGCCGTTTGCCGAAGTGGGGCGT
GCGCGTTCGGGCCATTGGGTGGACCAGGTCGTGCACGCTACCCGGGAACTGTCGGGATATCTGCGCGCGCAGCATCCCAT
GTCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5M9H7T3

Antitoxin

Source ID Structure
AlphaFold DB A0A366GQT1

References