Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4662180..4662800 Replicon chromosome
Accession NZ_CP045771
Organism Citrobacter braakii strain MiY-A

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GFC06_RS22000 Protein ID WP_002892050.1
Coordinates 4662582..4662800 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7L6U5G9
Locus tag GFC06_RS21995 Protein ID WP_019076175.1
Coordinates 4662180..4662554 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFC06_RS21985 4657326..4658519 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GFC06_RS21990 4658542..4661691 + 3150 WP_016152073.1 multidrug efflux RND transporter permease subunit -
GFC06_RS21995 4662180..4662554 + 375 WP_019076175.1 Hha toxicity modulator TomB Antitoxin
GFC06_RS22000 4662582..4662800 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GFC06_RS22005 4662981..4663532 + 552 WP_016152072.1 maltose O-acetyltransferase -
GFC06_RS22010 4663649..4664119 + 471 WP_016152071.1 YlaC family protein -
GFC06_RS22015 4664198..4664338 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
GFC06_RS22020 4664340..4664600 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
GFC06_RS22025 4664789..4666342 + 1554 WP_153690662.1 EAL domain-containing protein -
GFC06_RS22030 4666394..4666747 - 354 WP_003831033.1 DUF1428 family protein -
GFC06_RS22035 4666812..4667441 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T142528 WP_002892050.1 NZ_CP045771:4662582-4662800 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T142528 NZ_CP060712:2939460-2939870 [Phycicoccus endophyticus]
GTGGCAGTGACCGAGTGGCTGGTCGACAAGTCAGCCTTGGTCCGGCTGGGTGACAGCCCGGATGCGGAGGACTGGGCCGA
GCGGATCGAGCGAGGCTTGGTGCGCATCGCGACCGTGACCCGCTTGGAGGTCGGTTACTCCGCTCGCAGCGGTCACGACG
CCCGCGCCCTGTTCGCTCGGCCGCCGTTGTCCGCCATGCCGGTGGAGTACCTCACCCCGGCCATCGAGGATCGCGCGCTC
GACGTACAGCTGCTGCTGGCGGCACAGGGGCAGCATCGCGCCCCGTCGATCCCTGACCTCGTCATCGCCGCCGCCGCAGA
GCTTGCGGGGCTAACCGTGCTCCACCTCGACAAGGACTTCGACCTCATCGCCAGCATCACCGGCCAACCCGTCGAACGCC
TCAGTCTTTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14413.20 Da        Isoelectric Point: 5.5653

>AT142528 WP_019076175.1 NZ_CP045771:4662180-4662554 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT142528 NZ_CP060712:2939248-2939469 [Phycicoccus endophyticus]
GTGGCTGATGTCCTGATCCGCGATGTCCCCGACGCGGTTCTGGCTGGAGTTGACGCGCACGCCTCACGGTTGGGCCTATC
GCGGGTGGAGTACATCCGCCGACGTCTGGCCGCGGATGCGGCGACCTCGGAGAGCACGGTCTCCGGGTCCGACCTGCGCG
CGTTCGCCGACCTCGCCGGCGACCTGGATGATCCGCAGGTGATGGGCGCAGCGTGGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6U5G9

References