Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4551566..4552223 Replicon chromosome
Accession NZ_CP045769
Organism Enterobacter cancerogenus strain MiY-F

Toxin (Protein)


Gene name cptA Uniprot ID A0A5Q2KE30
Locus tag GH771_RS21285 Protein ID WP_058608592.1
Coordinates 4551813..4552223 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag GH771_RS21280 Protein ID WP_006178375.1
Coordinates 4551566..4551832 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH771_RS21260 4546986..4548419 - 1434 WP_153689438.1 6-phospho-beta-glucosidase BglA -
GH771_RS21265 4548535..4549266 - 732 WP_101738561.1 MurR/RpiR family transcriptional regulator -
GH771_RS21270 4549533..4550192 + 660 WP_006178378.1 hemolysin III family protein -
GH771_RS21275 4550291..4551271 - 981 WP_058608593.1 tRNA-modifying protein YgfZ -
GH771_RS21280 4551566..4551832 + 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
GH771_RS21285 4551813..4552223 + 411 WP_058608592.1 protein YgfX Toxin
GH771_RS21290 4552231..4552752 - 522 WP_006178373.1 flavodoxin FldB -
GH771_RS21295 4552854..4553750 + 897 WP_006178372.1 site-specific tyrosine recombinase XerD -
GH771_RS21300 4553779..4554492 + 714 WP_153689439.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GH771_RS21305 4554498..4556231 + 1734 WP_153689440.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16190.97 Da        Isoelectric Point: 11.1724

>T142512 WP_058608592.1 NZ_CP045769:4551813-4552223 [Enterobacter cancerogenus]
VVLWQSELRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDIIGTPWMLNSGMMLRLRSVDGERRQHLWLAADSMDAAEWRDLRRTMLQQPTQD

Download         Length: 411 bp

>T142512 NZ_CP060709:c2251957-2251706 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT142512 WP_006178375.1 NZ_CP045769:4551566-4551832 [Enterobacter cancerogenus]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT142512 NZ_CP060709:c2251709-2251455 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q2KE30

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References