Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2471069..2471689 Replicon chromosome
Accession NZ_CP045769
Organism Enterobacter cancerogenus strain MiY-F

Toxin (Protein)


Gene name Hha Uniprot ID D2ZG55
Locus tag GH771_RS11410 Protein ID WP_006176938.1
Coordinates 2471471..2471689 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID D2ZG56
Locus tag GH771_RS11405 Protein ID WP_006176939.1
Coordinates 2471069..2471443 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH771_RS11395 2466196..2467389 + 1194 WP_006176941.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GH771_RS11400 2467412..2470558 + 3147 WP_058609279.1 multidrug efflux RND transporter permease subunit AcrB -
GH771_RS11405 2471069..2471443 + 375 WP_006176939.1 Hha toxicity modulator TomB Antitoxin
GH771_RS11410 2471471..2471689 + 219 WP_006176938.1 hemolysin expression modulator Hha Toxin
GH771_RS11415 2471895..2472446 + 552 WP_088207831.1 maltose O-acetyltransferase -
GH771_RS11420 2472563..2473051 + 489 WP_042320836.1 membrane protein -
GH771_RS11425 2473002..2474462 - 1461 WP_153688877.1 PLP-dependent aminotransferase family protein -
GH771_RS11430 2474564..2475274 + 711 WP_153688878.1 GNAT family N-acetyltransferase -
GH771_RS11435 2475271..2475411 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
GH771_RS11440 2475414..2475674 - 261 WP_006176933.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T142509 WP_006176938.1 NZ_CP045769:2471471-2471689 [Enterobacter cancerogenus]
MSEKPLTKIDYLMRLRRCQSLDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T142509 NZ_CP060709:c2086227-2086124 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14467.25 Da        Isoelectric Point: 4.8886

>AT142509 WP_006176939.1 NZ_CP045769:2471069-2471443 [Enterobacter cancerogenus]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINASRANPVSLSC

Download         Length: 375 bp

>AT142509 NZ_CP060709:2086086-2086357 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D2ZG55

Antitoxin

Source ID Structure
AlphaFold DB D2ZG56

References