Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 5563414..5563919 Replicon chromosome
Accession NZ_CP045768
Organism Pseudomonas aeruginosa strain CFSAN084950

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag GFD20_RS25465 Protein ID WP_003083773.1
Coordinates 5563414..5563695 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag GFD20_RS25470 Protein ID WP_003083775.1
Coordinates 5563692..5563919 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GFD20_RS25440 5558665..5560014 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
GFD20_RS25445 5560063..5560749 + 687 WP_003083762.1 FadR family transcriptional regulator -
GFD20_RS25450 5560850..5561584 + 735 WP_003117208.1 GntR family transcriptional regulator -
GFD20_RS25455 5561788..5562174 + 387 WP_014602345.1 aegerolysin family protein -
GFD20_RS25460 5562206..5563114 - 909 WP_003083769.1 LysR family transcriptional regulator -
GFD20_RS25465 5563414..5563695 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
GFD20_RS25470 5563692..5563919 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
GFD20_RS25475 5564095..5564715 - 621 WP_003101226.1 hypothetical protein -
GFD20_RS25480 5564816..5565316 + 501 WP_003101228.1 LEA type 2 family protein -
GFD20_RS25485 5565389..5565730 + 342 WP_003101229.1 alkylphosphonate utilization protein -
GFD20_RS25490 5565812..5567239 - 1428 WP_003083784.1 GABA permease -
GFD20_RS25495 5567408..5568901 - 1494 WP_128570839.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T142500 WP_003083773.1 NZ_CP045768:c5563695-5563414 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T142500 NZ_CP060709:252300-252698 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT142500 WP_003083775.1 NZ_CP045768:c5563919-5563692 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT142500 NZ_CP060709:252004-252297 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References