Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2947536..2948149 Replicon chromosome
Accession NZ_CP045767
Organism Pseudomonas sp. CFSAN084952

Toxin (Protein)


Gene name hicA Uniprot ID A0A0W0N4L4
Locus tag GH769_RS12975 Protein ID WP_014718823.1
Coordinates 2947536..2947787 (+) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A854B833
Locus tag GH769_RS12980 Protein ID WP_014718824.1
Coordinates 2947784..2948149 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH769_RS12975 2947536..2947787 + 252 WP_014718823.1 type II toxin-antitoxin system HicA family toxin Toxin
GH769_RS12980 2947784..2948149 + 366 WP_014718824.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GH769_RS12985 2948150..2949322 - 1173 WP_014718825.1 MFS transporter -
GH769_RS12990 2949455..2950042 + 588 WP_032902897.1 TetR/AcrR family transcriptional regulator -
GH769_RS12995 2950026..2951381 - 1356 WP_014718827.1 MATE family efflux transporter -
GH769_RS13000 2951462..2952292 - 831 WP_019816829.1 IclR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9526.11 Da        Isoelectric Point: 10.0459

>T142493 WP_014718823.1 NZ_CP045767:2947536-2947787 [Pseudomonas sp. CFSAN084952]
VSKNEKLLAKLLNEHMAFTWSELVTLLRRLGYTQIEGAGSRVKFDMGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Download         Length: 252 bp

>T142493 NZ_CP060708:3262069-3262533 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13248.12 Da        Isoelectric Point: 7.3725

>AT142493 WP_014718824.1 NZ_CP045767:2947784-2948149 [Pseudomonas sp. CFSAN084952]
VNNQLKHKGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDAAFRGAVDDYLATCQSLGHTPEKPCKGSFNVRVGH
DLHLAAALAANRKKVTLNDLTRQALNEFLQHHYPEPCPTIG

Download         Length: 366 bp

>AT142493 NZ_CP060708:3261734-3262069 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0W0N4L4

Antitoxin

Source ID Structure
AlphaFold DB A0A854B833

References