Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | parE_1-relB/RelE(toxin) |
Location | 417842..418289 | Replicon | chromosome |
Accession | NZ_CP045767 | ||
Organism | Pseudomonas sp. CFSAN084952 |
Toxin (Protein)
Gene name | parE_1 | Uniprot ID | A0A854B692 |
Locus tag | GH769_RS01980 | Protein ID | WP_014717051.1 |
Coordinates | 418020..418289 (+) | Length | 90 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | A0A0W0ND88 |
Locus tag | GH769_RS01975 | Protein ID | WP_014717050.1 |
Coordinates | 417842..418030 (+) | Length | 63 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GH769_RS01950 | 413381..414712 | + | 1332 | WP_032903324.1 | aromatic acid/H+ symport family MFS transporter | - |
GH769_RS01955 | 414698..415501 | - | 804 | WP_020301219.1 | tetratricopeptide repeat protein | - |
GH769_RS01960 | 415689..416708 | + | 1020 | WP_014717048.1 | Glu/Leu/Phe/Val dehydrogenase | - |
GH769_RS01965 | 416764..417024 | - | 261 | WP_003188807.1 | YebG family protein | - |
GH769_RS01970 | 417445..417690 | + | 246 | WP_014717049.1 | hypothetical protein | - |
GH769_RS01975 | 417842..418030 | + | 189 | WP_014717050.1 | hypothetical protein | Antitoxin |
GH769_RS01980 | 418020..418289 | + | 270 | WP_014717051.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
GH769_RS01985 | 418459..418947 | + | 489 | WP_014717052.1 | phosphate-starvation-inducible PsiE family protein | - |
GH769_RS01990 | 418944..419261 | - | 318 | WP_032893434.1 | DUF3509 domain-containing protein | - |
GH769_RS01995 | 419527..420816 | - | 1290 | WP_014717054.1 | HAAAP family serine/threonine permease | - |
GH769_RS02000 | 420878..422254 | - | 1377 | WP_019817648.1 | L-serine ammonia-lyase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 90 a.a. Molecular weight: 10381.24 Da Isoelectric Point: 10.9886
>T142491 WP_014717051.1 NZ_CP045767:418020-418289 [Pseudomonas sp. CFSAN084952]
MLIEWLPAARVELRQIIEYLSHRNPVAALELKRSIEASVLALSRRPHLYRPGRIGGTREMVVHPNYLVVYKVTDNIRILS
VLHARQRYP
MLIEWLPAARVELRQIIEYLSHRNPVAALELKRSIEASVLALSRRPHLYRPGRIGGTREMVVHPNYLVVYKVTDNIRILS
VLHARQRYP
Download Length: 270 bp
>T142491 NZ_CP060708:c3153276-3152980 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 63 a.a. Molecular weight: 6884.55 Da Isoelectric Point: 4.0061
>AT142491 WP_014717050.1 NZ_CP045767:417842-418030 [Pseudomonas sp. CFSAN084952]
MDTSFSSGIQADIEEQADSYDRWFRARVQAALDDPSPGIPHDEVMAEMQALIESKLKKGDAD
MDTSFSSGIQADIEEQADSYDRWFRARVQAALDDPSPGIPHDEVMAEMQALIESKLKKGDAD
Download Length: 189 bp
>AT142491 NZ_CP060708:c3152978-3152583 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A854B692 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0W0ND88 |