Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parE_1-relB/RelE(toxin)
Location 417842..418289 Replicon chromosome
Accession NZ_CP045767
Organism Pseudomonas sp. CFSAN084952

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A854B692
Locus tag GH769_RS01980 Protein ID WP_014717051.1
Coordinates 418020..418289 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0W0ND88
Locus tag GH769_RS01975 Protein ID WP_014717050.1
Coordinates 417842..418030 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH769_RS01950 413381..414712 + 1332 WP_032903324.1 aromatic acid/H+ symport family MFS transporter -
GH769_RS01955 414698..415501 - 804 WP_020301219.1 tetratricopeptide repeat protein -
GH769_RS01960 415689..416708 + 1020 WP_014717048.1 Glu/Leu/Phe/Val dehydrogenase -
GH769_RS01965 416764..417024 - 261 WP_003188807.1 YebG family protein -
GH769_RS01970 417445..417690 + 246 WP_014717049.1 hypothetical protein -
GH769_RS01975 417842..418030 + 189 WP_014717050.1 hypothetical protein Antitoxin
GH769_RS01980 418020..418289 + 270 WP_014717051.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GH769_RS01985 418459..418947 + 489 WP_014717052.1 phosphate-starvation-inducible PsiE family protein -
GH769_RS01990 418944..419261 - 318 WP_032893434.1 DUF3509 domain-containing protein -
GH769_RS01995 419527..420816 - 1290 WP_014717054.1 HAAAP family serine/threonine permease -
GH769_RS02000 420878..422254 - 1377 WP_019817648.1 L-serine ammonia-lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10381.24 Da        Isoelectric Point: 10.9886

>T142491 WP_014717051.1 NZ_CP045767:418020-418289 [Pseudomonas sp. CFSAN084952]
MLIEWLPAARVELRQIIEYLSHRNPVAALELKRSIEASVLALSRRPHLYRPGRIGGTREMVVHPNYLVVYKVTDNIRILS
VLHARQRYP

Download         Length: 270 bp

>T142491 NZ_CP060708:c3153276-3152980 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6884.55 Da        Isoelectric Point: 4.0061

>AT142491 WP_014717050.1 NZ_CP045767:417842-418030 [Pseudomonas sp. CFSAN084952]
MDTSFSSGIQADIEEQADSYDRWFRARVQAALDDPSPGIPHDEVMAEMQALIESKLKKGDAD

Download         Length: 189 bp

>AT142491 NZ_CP060708:c3152978-3152583 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854B692

Antitoxin

Source ID Structure
AlphaFold DB A0A0W0ND88

References