Detailed information of TA system TA142490

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ykfI-yfjZ/CbtA-CbeA
• Location: 4410369..4411095
• Replicon: chromosome
• Accession: NZ_CP045766
• Organism: Salmonella bongori CFSAN000510 strain SGSC 3100

Toxin (Protein)

• Gene name: ykfI
• Uniprot ID: A0A248KBV8
• Locus tag: GH767_RS20725
• Protein ID: WP_001194750.1
• Coordinates: 4410369..4410710 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A248KCL1
• Locus tag: GH767_RS20730
• Protein ID: WP_000380487.1
• Coordinates: 4410754..4411095 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GH767_RS20705	4406249..4407568	+	1320	WP_001218450.1	site-specific integrase	-
GH767_RS20710	4407606..4408658	-	1053	WP_000575274.1	macro domain-containing protein	-
GH767_RS20715	4408672..4409319	-	648	WP_000026701.1	DUF4433 domain-containing protein	-
GH767_RS20720	4409420..4410253	-	834	WP_001192753.1	DUF4942 domain-containing protein	-
GH767_RS20725	4410369..4410710	-	342	WP_001194750.1	TA system toxin CbtA family protein	Toxin
GH767_RS20730	4410754..4411095	-	342	WP_000380487.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
GH767_RS20735	4411118..4411339	-	222	WP_000691988.1	DUF987 family protein	-
GH767_RS20740	4411336..4411836	-	501	WP_001090292.1	DNA repair protein RadC	-
GH767_RS20745	4411849..4412667	-	819	WP_001234407.1	DUF945 domain-containing protein	-
GH767_RS20750	4412769..4413014	-	246	WP_000082136.1	DUF905 domain-containing protein	-
GH767_RS20755	4413089..4414003	-	915	WP_000797249.1	hypothetical protein	-
GH767_RS20760	4414068..4414271	-	204	WP_000508162.1	hypothetical protein	-
GH767_RS21050	4414288..4414434	-	147	WP_023892166.1	hypothetical protein	-
GH767_RS20765	4414507..4415221	-	715	Protein_4033	WYL domain-containing protein	-
GH767_RS20770	4415574..4415879	-	306	WP_000227087.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4385774..4428729	42955

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (2-109)

Antitoxin

• Antitoxin CbeA (11-109)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 13116.01 Da
• Isoelectric Point: 9.7617

>T142490 WP_001194750.1 NZ_CP045766:c4410710-4410369 [Salmonella bongori CFSAN000510]
MQTQYNHPHRATPSQPSPVEIWQKLLTHLLAKHYGLELSDTPFSVEKVIQEHIDAGITLANAVNFIVEKYELVRIDRKGF
SWQEQSPYLRAVDILRARQATGLLRRQRYLAAH

Nucleotide

• Length: 342 bp

>T142490 NZ_CP060708:c3025555-3025148 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12770.65 Da
• Isoelectric Point: 9.4771

>AT142490 WP_000380487.1 NZ_CP045766:c4411095-4410754 [Salmonella bongori CFSAN000510]
MDTNETQSTPVWGLRNDVFPSFGARLVQEGNHLHYLADRAGIYGEFTPAQLKTLNIVFPMFIKRMEVALRTGALNPREAR
RFTTALRGIICEADTRGSFGYVYLSLYPTVVKN

Nucleotide

• Length: 342 bp

>AT142490 NZ_CP060708:c3025802-3025536 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A248KBV8

Antitoxin

• AlphaFold DB: A0A248KCL1