Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4255698..4256318 Replicon chromosome
Accession NZ_CP045766
Organism Salmonella bongori CFSAN000510 strain SGSC 3100

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag GH767_RS20030 Protein ID WP_001280991.1
Coordinates 4256100..4256318 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag GH767_RS20025 Protein ID WP_000344807.1
Coordinates 4255698..4256072 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH767_RS20015 4250837..4252030 + 1194 WP_001039205.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GH767_RS20020 4252053..4255202 + 3150 WP_001132513.1 multidrug efflux RND transporter permease subunit -
GH767_RS20025 4255698..4256072 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
GH767_RS20030 4256100..4256318 + 219 WP_001280991.1 hemolysin expression modulator Hha Toxin
GH767_RS20035 4256497..4257048 + 552 WP_001278796.1 maltose O-acetyltransferase -
GH767_RS20040 4257166..4257636 + 471 WP_000136180.1 YlaC family protein -
GH767_RS20045 4257689..4257829 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
GH767_RS20050 4257835..4258095 - 261 WP_000801419.1 type B 50S ribosomal protein L31 -
GH767_RS20055 4258300..4259850 + 1551 WP_000213124.1 EAL domain-containing protein -
GH767_RS20065 4260089..4260478 + 390 WP_000908589.1 MGMT family protein -
GH767_RS20070 4260511..4261080 - 570 WP_000779806.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T142489 WP_001280991.1 NZ_CP045766:4256100-4256318 [Salmonella bongori CFSAN000510]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T142489 NZ_CP060708:c2895822-2895487 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT142489 WP_000344807.1 NZ_CP045766:4255698-4256072 [Salmonella bongori CFSAN000510]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT142489 NZ_CP060708:c2896070-2895822 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References