Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3228560..3229302 Replicon chromosome
Accession NZ_CP045766
Organism Salmonella bongori CFSAN000510 strain SGSC 3100

Toxin (Protein)


Gene name tacT Uniprot ID A0A248K916
Locus tag GH767_RS15085 Protein ID WP_000521216.1
Coordinates 3228814..3229302 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID S5MPV7
Locus tag GH767_RS15080 Protein ID WP_020844238.1
Coordinates 3228560..3228826 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH767_RS15070 3223799..3226327 + 2529 WP_000613169.1 malto-oligosyltrehalose synthase -
GH767_RS15075 3226370..3228445 + 2076 WP_000210608.1 glycogen debranching protein GlgX -
GH767_RS15080 3228560..3228826 + 267 WP_020844238.1 DUF1778 domain-containing protein Antitoxin
GH767_RS15085 3228814..3229302 + 489 WP_000521216.1 GNAT family N-acetyltransferase Toxin
GH767_RS15090 3229860..3230249 + 390 WP_015702869.1 RidA family protein -
GH767_RS15095 3230317..3231396 - 1080 WP_000954703.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
GH767_RS15100 3231573..3232061 - 489 WP_001293644.1 MarR family winged helix-turn-helix transcriptional regulator -
GH767_RS15105 3232106..3233614 + 1509 WP_000196705.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(32-151)

Antitoxin

Vibrio phage ICP1, Orf50

(4-87)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17719.47 Da        Isoelectric Point: 9.5852

>T142488 WP_000521216.1 NZ_CP045766:3228814-3229302 [Salmonella bongori CFSAN000510]
VGKVTAPAPLSTLHNLAEFCCGESLLDDWLRQRALKNQATGASRTFVVCKAASHQVVGFYSLATGSVNHAEATGGLRRNM
PDPIPVIILARLAVDVSYHGIGLGADLLRDAILRAYRVAENIGVRAMVVQALTEQAKRFYLHHGFRESGKQERTLFLILP
ER

Download         Length: 489 bp

>T142488 NZ_CP060708:2763141-2763470 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9999.47 Da        Isoelectric Point: 4.7961

>AT142488 WP_020844238.1 NZ_CP045766:3228560-3228826 [Salmonella bongori CFSAN000510]
MKSGVQLNIRAKESQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRVFNLNDDQYAEFVEMLDAPVATNPALDNLL
ARKPLWEK

Download         Length: 267 bp

>AT142488 NZ_CP060708:2762803-2763120 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248K916

Antitoxin

Source ID Structure
AlphaFold DB S5MPV7

References