Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1829407..1830067 Replicon chromosome
Accession NZ_CP045766
Organism Salmonella bongori CFSAN000510 strain SGSC 3100

Toxin (Protein)


Gene name cptA Uniprot ID S5NC56
Locus tag GH767_RS08545 Protein ID WP_000244759.1
Coordinates 1829654..1830067 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag GH767_RS08540 Protein ID WP_000351186.1
Coordinates 1829407..1829673 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH767_RS08520 1825404..1826837 - 1434 WP_000737109.1 6-phospho-beta-glucosidase -
GH767_RS08525 1826995..1827306 + 312 WP_015702996.1 N(4)-acetylcytidine aminohydrolase -
GH767_RS08530 1827470..1828129 + 660 WP_024135108.1 hemolysin III family protein -
GH767_RS08535 1828180..1829160 - 981 WP_000896119.1 tRNA-modifying protein YgfZ -
GH767_RS08540 1829407..1829673 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
GH767_RS08545 1829654..1830067 + 414 WP_000244759.1 protein YgfX Toxin
GH767_RS08550 1830119..1830640 - 522 WP_001055887.1 flavodoxin FldB -
GH767_RS08555 1830753..1831649 + 897 WP_000806655.1 site-specific tyrosine recombinase XerD -
GH767_RS08560 1831673..1832386 + 714 WP_000745612.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GH767_RS08565 1832392..1834125 + 1734 WP_000813377.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16190.13 Da        Isoelectric Point: 9.4274

>T142479 WP_000244759.1 NZ_CP045766:1829654-1830067 [Salmonella bongori CFSAN000510]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMMLLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGE
DWVLLRPPWLLNSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRVMLQQPLSGQH

Download         Length: 414 bp

>T142479 NZ_CP060708:c1398377-1398183 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGGTTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT142479 WP_000351186.1 NZ_CP045766:1829407-1829673 [Salmonella bongori CFSAN000510]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT142479 NZ_CP060708:1398006-1398184 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S5NC56

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References