Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 27497..28019 Replicon plasmid p2CFSAN000318
Accession NZ_CP045764
Organism Salmonella enterica subsp. enterica serovar Heidelberg str. 41578

Toxin (Protein)


Gene name relE Uniprot ID D0QMR1
Locus tag GH765_RS24025 Protein ID WP_000220561.1
Coordinates 27497..27778 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G3CAG1
Locus tag GH765_RS24030 Protein ID WP_000121743.1
Coordinates 27768..28019 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH765_RS23980 22768..23115 - 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -
GH765_RS23985 23112..23360 - 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin -
GH765_RS23990 23665..24015 - 351 WP_000854259.1 hypothetical protein -
GH765_RS23995 24106..24405 - 300 WP_000650309.1 hypothetical protein -
GH765_RS24000 24859..25086 - 228 WP_000801440.1 hypothetical protein -
GH765_RS24005 25073..25324 - 252 WP_001230707.1 hypothetical protein -
GH765_RS24010 25321..25863 - 543 WP_001083906.1 hypothetical protein -
GH765_RS24015 25968..26483 - 516 WP_001025395.1 J domain-containing protein -
GH765_RS24020 27123..27473 - 351 WP_000312755.1 hypothetical protein -
GH765_RS24025 27497..27778 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GH765_RS24030 27768..28019 - 252 WP_000121743.1 plasmid stabilization protein Antitoxin
GH765_RS24035 29385..30392 + 1008 WP_000243325.1 replication initiation protein -
GH765_RS24040 30458..30862 + 405 WP_000654312.1 hypothetical protein -
GH765_RS24045 30998..31525 + 528 WP_000577047.1 DUF2726 domain-containing protein -
GH765_RS24050 32097..32348 - 252 WP_000905714.1 hypothetical protein -
GH765_RS24055 32385..32687 - 303 WP_001062963.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..35297 35297


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 13852.62 Da        Isoelectric Point: 5.5500

>T142478 WP_000220561.1 NZ_CP045764:c27778-27497 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Download         Length: 282 bp

>T142478 NZ_CP060708:c1269750-1269643 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 12380.85 Da        Isoelectric Point: 5.5500

>AT142478 WP_000121743.1 NZ_CP045764:c28019-27768 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Download         Length: 252 bp

>AT142478 NZ_CP060708:1269797-1269863 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S5I302

Antitoxin

Source ID Structure
AlphaFold DB A0A3S5I301

References