142477

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 24859..25324 Replicon plasmid p2CFSAN000318
Accession NZ_CP045764
Organism Salmonella enterica subsp. enterica serovar Heidelberg str. 41578

Toxin (Protein)


Gene name TsxA Uniprot ID U9ZUY2
Locus tag GH765_RS24005 Protein ID WP_001230707.1
Coordinates 25073..25324 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag GH765_RS24000 Protein ID WP_000801440.1
Coordinates 24859..25086 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH765_RS23960 20089..20322 - 234 WP_000120384.1 EexN family lipoprotein -
GH765_RS23965 20327..20593 - 267 WP_000134734.1 hypothetical protein -
GH765_RS23970 20670..21899 - 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
GH765_RS23975 21903..22406 - 504 WP_000781816.1 hypothetical protein -
GH765_RS23980 22768..23115 - 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin -
GH765_RS23985 23112..23360 - 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin -
GH765_RS23990 23665..24015 - 351 WP_000854259.1 hypothetical protein -
GH765_RS23995 24106..24405 - 300 WP_000650309.1 hypothetical protein -
GH765_RS24000 24859..25086 - 228 WP_000801440.1 hypothetical protein Antitoxin
GH765_RS24005 25073..25324 - 252 WP_001230707.1 hypothetical protein Toxin
GH765_RS24010 25321..25863 - 543 WP_001083906.1 hypothetical protein -
GH765_RS24015 25968..26483 - 516 WP_001025395.1 J domain-containing protein -
GH765_RS24020 27123..27473 - 351 WP_000312755.1 hypothetical protein -
GH765_RS24025 27497..27778 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin -
GH765_RS24030 27768..28019 - 252 WP_000121743.1 plasmid stabilization protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..35297 35297


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 12380.85 Da        Isoelectric Point: 5.5500

>T142477 WP_001230707.1 NZ_CP045764:c25324-25073 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFF

Download         Length: 252 bp

>T142477 NZ_CP060708:c1269215-1269108 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 11203.44 Da        Isoelectric Point: 5.5500

>AT142477 WP_000801440.1 NZ_CP045764:c25086-24859 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 228 bp

>AT142477 NZ_CP060708:1269262-1269328 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZUY2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References