Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 22768..23360 Replicon plasmid p2CFSAN000318
Accession NZ_CP045764
Organism Salmonella enterica subsp. enterica serovar Heidelberg str. 41578

Toxin (Protein)


Gene name hicA Uniprot ID V0AGQ2
Locus tag GH765_RS23985 Protein ID WP_000520549.1
Coordinates 23112..23360 (-) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V0AWG0
Locus tag GH765_RS23980 Protein ID WP_000681613.1
Coordinates 22768..23115 (-) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH765_RS23950 18769..19041 - 273 WP_001328551.1 TrbC/VirB2 family protein -
GH765_RS23955 19109..19729 - 621 WP_000157549.1 lytic transglycosylase domain-containing protein -
GH765_RS23960 20089..20322 - 234 WP_000120384.1 EexN family lipoprotein -
GH765_RS23965 20327..20593 - 267 WP_000134734.1 hypothetical protein -
GH765_RS23970 20670..21899 - 1230 WP_001329504.1 relaxase/mobilization nuclease domain-containing protein -
GH765_RS23975 21903..22406 - 504 WP_000781816.1 hypothetical protein -
GH765_RS23980 22768..23115 - 348 WP_000681613.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GH765_RS23985 23112..23360 - 249 WP_000520549.1 type II toxin-antitoxin system HicA family toxin Toxin
GH765_RS23990 23665..24015 - 351 WP_000854259.1 hypothetical protein -
GH765_RS23995 24106..24405 - 300 WP_000650309.1 hypothetical protein -
GH765_RS24000 24859..25086 - 228 WP_000801440.1 hypothetical protein -
GH765_RS24005 25073..25324 - 252 WP_001230707.1 hypothetical protein -
GH765_RS24010 25321..25863 - 543 WP_001083906.1 hypothetical protein -
GH765_RS24015 25968..26483 - 516 WP_001025395.1 J domain-containing protein -
GH765_RS24020 27123..27473 - 351 WP_000312755.1 hypothetical protein -
GH765_RS24025 27497..27778 - 282 WP_000220561.1 type II toxin-antitoxin system RelE/ParE family toxin -
GH765_RS24030 27768..28019 - 252 WP_000121743.1 plasmid stabilization protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..35297 35297


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 12233.67 Da        Isoelectric Point: 5.5500

>T142476 WP_000520549.1 NZ_CP045764:c23360-23112 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFF

Download         Length: 249 bp

>T142476 NZ_CP060708:c1268680-1268573 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 17090.50 Da        Isoelectric Point: 5.5500

>AT142476 WP_000681613.1 NZ_CP045764:c23115-22768 [Salmonella enterica subsp. enterica serovar Heidelberg str. 41578]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 348 bp

>AT142476 NZ_CP060708:1268728-1268794 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CIX3

Antitoxin

Source ID Structure
AlphaFold DB A0A829CLC1

References