Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 29279..29826 Replicon plasmid pCFSAN000661
Accession NZ_CP045760
Organism Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000661

Toxin (Protein)


Gene name parE Uniprot ID A0A4D6NZF1
Locus tag GH762_RS22825 Protein ID WP_000970006.1
Coordinates 29279..29560 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A4D6P197
Locus tag GH762_RS22830 Protein ID WP_000084547.1
Coordinates 29557..29826 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH762_RS22805 24703..25404 - 702 WP_023251326.1 transcriptional activator SprB -
GH762_RS22810 25601..26473 - 873 WP_077915507.1 helix-turn-helix transcriptional regulator -
GH762_RS22815 26782..27291 - 510 WP_131535394.1 hypothetical protein -
GH762_RS22820 28537..29127 + 591 WP_031607984.1 plasmid pRiA4b ORF-3 family protein -
GH762_RS22825 29279..29560 - 282 WP_000970006.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GH762_RS22830 29557..29826 - 270 WP_000084547.1 hypothetical protein Antitoxin
GH762_RS22835 30782..31663 - 882 WP_023193063.1 incFII family plasmid replication initiator RepA -
GH762_RS22840 31644..31721 - 78 WP_001541552.1 RepA leader peptide Tap -
GH762_RS22845 31971..32237 - 267 WP_001576653.1 replication regulatory protein RepA -
GH762_RS22850 32381..32851 - 471 Protein_32 phospholipase D family protein -
GH762_RS22855 33091..33822 - 732 WP_020833545.1 type-F conjugative transfer system pilin acetylase TraX -
GH762_RS22860 33819..34385 - 567 WP_000493830.1 DUF2726 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81815 81815


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 13852.62 Da        Isoelectric Point: 5.5500

>T142475 WP_000970006.1 NZ_CP045760:c29560-29279 [Salmonella enterica subsp. enterica serovar Bareilly str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFF

Download         Length: 282 bp

>T142475 NZ_CP060708:c479532-479314 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 13263.91 Da        Isoelectric Point: 5.5500

>AT142475 WP_000084547.1 NZ_CP045760:c29826-29557 [Salmonella enterica subsp. enterica serovar Bareilly str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFF

Download         Length: 270 bp

>AT142475 NZ_CP060708:c479932-479558 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D6NZF1

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P197

References