Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 32216..32763 Replicon plasmid pCFSAN000669
Accession NZ_CP045758
Organism Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000669

Toxin (Protein)


Gene name parE Uniprot ID A0A4D6NZF1
Locus tag GH763_RS22850 Protein ID WP_000970006.1
Coordinates 32482..32763 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A4D6P197
Locus tag GH763_RS22845 Protein ID WP_000084547.1
Coordinates 32216..32485 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH763_RS22815 27657..28223 + 567 WP_000493830.1 DUF2726 domain-containing protein -
GH763_RS22820 28220..28951 + 732 WP_020833545.1 type-F conjugative transfer system pilin acetylase TraX -
GH763_RS22825 29191..29661 + 471 Protein_26 phospholipase D family protein -
GH763_RS22830 29805..30071 + 267 WP_001576653.1 replication regulatory protein RepA -
GH763_RS22835 30321..30398 + 78 WP_001541552.1 RepA leader peptide Tap -
GH763_RS22840 30379..31260 + 882 WP_023193063.1 incFII family plasmid replication initiator RepA -
GH763_RS22845 32216..32485 + 270 WP_000084547.1 hypothetical protein Antitoxin
GH763_RS22850 32482..32763 + 282 WP_000970006.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GH763_RS22855 32915..33505 - 591 WP_031607984.1 plasmid pRiA4b ORF-3 family protein -
GH763_RS22860 34751..35260 + 510 WP_131535394.1 hypothetical protein -
GH763_RS22865 35569..36441 + 873 WP_077915507.1 helix-turn-helix transcriptional regulator -
GH763_RS22870 36638..37339 + 702 WP_023251326.1 transcriptional activator SprB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81815 81815


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-92)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T142472 WP_000970006.1 NZ_CP045758:32482-32763 [Salmonella enterica subsp. enterica serovar Bareilly str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T142472 NZ_CP060708:c246239-245961 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 11553.68 Da        Isoelectric Point: 12.7493

>AT142472 WP_000084547.1 NZ_CP045758:32216-32485 [Salmonella enterica subsp. enterica serovar Bareilly str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Download         Length: 270 bp

>AT142472 NZ_CP060708:c246502-246242 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D6NZF1

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P197

References