Detailed information of TA system TA142471

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 50131..50666
• Replicon: plasmid p2CFSAN000752
• Accession: NZ_CP045756
• Organism: Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000752

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GH764_RS23375
• Protein ID: WP_000221869.1
• Coordinates: 50379..50666 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GH764_RS23370
• Protein ID: WP_001132897.1
• Coordinates: 50131..50382 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GH764_RS23350	45725..46258	-	534	WP_001372168.1	transcription termination factor NusG	-
GH764_RS23355	46700..46987	-	288	WP_000074855.1	conjugal transfer protein TraA	-
GH764_RS23360	46905..47168	-	264	WP_023156844.1	ash family protein	-
GH764_RS23365	48139..49170	+	1032	WP_000907868.1	replication initiation protein	-
GH764_RS23370	50131..50382	+	252	WP_001132897.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GH764_RS23375	50379..50666	+	288	WP_000221869.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GH764_RS23380	50972..52139	-	1168	Protein_53	IS91 family transposase	-
GH764_RS23385	52143..52412	-	270	WP_001371878.1	hypothetical protein	-
GH764_RS23735	52483..52665	+	183	Protein_55	helix-turn-helix domain-containing protein	-
GH764_RS23390	53358..53600	+	243	WP_071781016.1	Dabb family protein	-
GH764_RS23395	53697..54425	+	729	WP_047642110.1	hypothetical protein	-
GH764_RS23400	54493..54993	+	501	WP_021555210.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..99458	99458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-77)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 12322.73 Da
• Isoelectric Point: 12.7777

>T142471 WP_000221869.1 NZ_CP045756:50379-50666 [Salmonella enterica subsp. enterica serovar Bareilly str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKKKK

Nucleotide

• Length: 288 bp

>T142471 NZ_CP060707:c1641989-1641702 [Campylobacter concisus]
ATGAGCTATGAGTTAGAGTTCTTACCAGGCGCTTTAAAAGAGTGGCAAAAGCTAGACAATAGCATAAAAGTGCAGTTTAA
AAAGAAGCTAAGTGAGCGTCTAGAAAACCCAAAGGTTGCCAAGGACAAGCTACGAGGCTACGAAGATGTCTATAAGATCA
AGTTAAGAGATGTCGGCTACCGCTTGGCATATCAGGTAAAAGATAGTGAGATAGTAGTGTTAGTGCTAGTTGTCGGCAAA
AGAGAGAACAACGAAGTATACGAGATGCTAAAGGATAAATTTAACTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 10784.64 Da
• Isoelectric Point: 12.7191

>AT142471 WP_001132897.1 NZ_CP045756:50131-50382 [Salmonella enterica subsp. enterica serovar Bareilly str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKK

Nucleotide

• Length: 252 bp

>AT142471 NZ_CP060707:c1642230-1641979 [Campylobacter concisus]
ATGCAAACTATACAAGCAAATTTTACAGCTAGCATAAGTGAGCTAAAAAAGTCTCCAGCTCAAATTTTAAAACAAGCTGG
AGATAATGTCGTAGCTATACTAAACCACAATGTCCCTAGCGCATATCTAGTACCAAGTGCTGTCTATGAAAAAATGGCAG
AGATAATAGAAGAGTATCATCTAAGTAAAGCAGTAGATGCTGCTCTAGCAAGTGGTGAAAAACCAGTAAAAGTAAGCTTA
GATGAGCTATGA