Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 56461..56986 Replicon plasmid p1CFSAN000752
Accession NZ_CP045755
Organism Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000752

Toxin (Protein)


Gene name ccdB Uniprot ID A0A4D6P1W7
Locus tag GH764_RS23005 Protein ID WP_020833585.1
Coordinates 56461..56766 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID I3VZQ6
Locus tag GH764_RS23010 Protein ID WP_000813642.1
Coordinates 56768..56986 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH764_RS22985 51499..52704 - 1206 WP_000427674.1 AAA family ATPase -
GH764_RS22990 53393..53647 - 255 WP_001749329.1 hypothetical protein -
GH764_RS22995 54278..55219 + 942 WP_000728920.1 Rpn family recombination-promoting nuclease/putative transposase -
GH764_RS23000 55370..56152 - 783 WP_020833584.1 site-specific integrase -
GH764_RS23005 56461..56766 - 306 WP_020833585.1 type II toxin-antitoxin system toxin CcdB Toxin
GH764_RS23010 56768..56986 - 219 WP_000813642.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
GH764_RS23015 57806..58177 - 372 WP_100215268.1 DUF1311 domain-containing protein -
GH764_RS23020 58965..59687 - 723 WP_000742239.1 LuxR C-terminal-related transcriptional regulator -
GH764_RS23025 59886..60938 - 1053 WP_020833588.1 Ig-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81815 81815


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-77)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 15030.03 Da        Isoelectric Point: 5.5500

>T142470 WP_020833585.1 NZ_CP045755:c56766-56461 [Salmonella enterica subsp. enterica serovar Bareilly str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFF

Download         Length: 306 bp

>T142470 NZ_CP060705:c1628772-1628485 [Campylobacter concisus]
ATGAGCTATGAGTTAGAGTTCTTACCAGGCGCTTTAAAAGAGTGGCAAAAGCTAGACAATAGCATAAAAGTGCAGTTTAA
AAAGAAGCTAAGTGAGCGTCTAGAAAACCCAAAGGTTGCCAAGGACAAGCTACGAGGCTACGAAGATGTCTATAAGATCA
AGTTAAGAGATGTCGGCTACCGCTTGGCATATCAGGTAAAAGATAGTGAGATAGTAGTGTTAGTGCTAGTTGTCGGCAAA
AGAGAGAACAACGAAGTATACGAGATGCTAAAGGATAAATTTAACTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 10761.91 Da        Isoelectric Point: 5.5500

>AT142470 WP_000813642.1 NZ_CP045755:c56986-56768 [Salmonella enterica subsp. enterica serovar Bareilly str.]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Download         Length: 219 bp

>AT142470 NZ_CP060705:c1629013-1628762 [Campylobacter concisus]
ATGCAAACTATACAAGCAAATTTTACAGCTAGCATAAGTGAGCTAAAAAAGTCTCCAGCTCAAATTTTAAAACAAGCTGG
AGATAATGTCGTAGCTATACTAAACCACAATGTCCCTAGCGCATATCTAGTACCAAGTGCTGTCTATGAAAAAATGGCAG
AGATAATAGAAGAGTATCATCTAAGTAAAGCAGTAGATGCTGCTCTAGCAAGTGGTGAAAAACCAGTAAAAGTAAGCTTA
GATGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D6P1W7

Antitoxin

Source ID Structure
AlphaFold DB A0A600YYQ0

References