Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelE-RHH
Location 56134..56681 Replicon plasmid pCFSAN000189
Accession NZ_CP045752
Organism Salmonella enterica subsp. enterica serovar Bareilly str. CFSAN000189

Toxin (Protein)


Gene name parE Uniprot ID A0A4D6NZF1
Locus tag GH766_RS00320 Protein ID WP_000970006.1
Coordinates 56400..56681 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A4D6P197
Locus tag GH766_RS00315 Protein ID WP_000084547.1
Coordinates 56134..56403 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH766_RS00285 51575..52141 + 567 WP_000493830.1 DUF2726 domain-containing protein -
GH766_RS00290 52138..52869 + 732 WP_020833545.1 type-F conjugative transfer system pilin acetylase TraX -
GH766_RS00295 53109..53579 + 471 Protein_58 phospholipase D family protein -
GH766_RS00300 53723..53989 + 267 WP_001576653.1 replication regulatory protein RepA -
GH766_RS00305 54239..54316 + 78 WP_001541552.1 RepA leader peptide Tap -
GH766_RS00310 54297..55178 + 882 WP_023193063.1 incFII family plasmid replication initiator RepA -
GH766_RS00315 56134..56403 + 270 WP_000084547.1 hypothetical protein Antitoxin
GH766_RS00320 56400..56681 + 282 WP_000970006.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
GH766_RS00325 56833..57423 - 591 WP_031607984.1 plasmid pRiA4b ORF-3 family protein -
GH766_RS00330 58669..59178 + 510 WP_131535394.1 hypothetical protein -
GH766_RS00335 59487..60359 + 873 WP_077915507.1 helix-turn-helix transcriptional regulator -
GH766_RS00340 60556..61257 + 702 WP_023251326.1 transcriptional activator SprB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81815 81815


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Toxin HigB-like

(13-90)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 12066.38 Da        Isoelectric Point: 12.7685

>T142469 WP_000970006.1 NZ_CP045752:56400-56681 [Salmonella enterica subsp. enterica serovar Bareilly str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKKKKKK

Download         Length: 282 bp

>T142469 NZ_CP060704:5459989-5460294 [Chitinimonas koreensis]
ATGGCAGACACTGCAACCCGCGCCTGGGACCCGGCGGAACACCTCGATAGCGAAGAAGATATGGCGGCCTATCTCGAGGC
CGCCCTCGAAGACGGCGACCCGGCCCTGGTCACCGCCGCCTTGGGCGATATCGCCCGCGCCAAGGGCATGACCCGCATCG
CGCGCGAGGCCGGTCTGAGCCGCGAAAGCCTGTACAAGGCGCTTTCGCCCAACGGCAACCCGGAGCTGGCGACGATCCTG
AAGGTCGTCTCCGTGCTCGGCCTGCGGCTGCACGCTACCCCCGCACCGGCGAAGCTACCGGGATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 11553.68 Da        Isoelectric Point: 12.7493

>AT142469 WP_000084547.1 NZ_CP045752:56134-56403 [Salmonella enterica subsp. enterica serovar Bareilly str.]
KKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKKK
KKKKKKKKKK

Download         Length: 270 bp

>AT142469 NZ_CP060704:5459688-5459978 [Chitinimonas koreensis]
ATGGTCGAGATACGTCAAACGGACGGTTACGCCCACTGGTTCGCAGGACTGCGGGATCGCACGGCACGCGCCCGGATCGA
CATCCGCATCCGCCGCCTGTCGCTCGACAACCCCGGCGACGTCAAACCCGTAGGCGGCGGCGTATCCGAGCTTCGCATCG
ACCGTGGGCCGGGCTATCGCATCTACTTCGTCCGGCGCGGCGACACGCTCGTCGTCCTGCTGGCCGGCGGCGGCAAGTCC
ACGCAGGAACAGGACATCCGGAACGCGCTCGAACTGGCCCGTTCGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D6NZF1

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P197

References