Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 794967..795596 Replicon chromosome
Accession NZ_CP045743
Organism Listeria innocua strain CFSAN044836

Toxin (Protein)


Gene name pemK Uniprot ID Q92DC7
Locus tag GH761_RS04070 Protein ID WP_010990666.1
Coordinates 794967..795314 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H1GC21
Locus tag GH761_RS04075 Protein ID WP_003761302.1
Coordinates 795318..795596 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH761_RS04035 790375..791154 - 780 WP_010990669.1 RNA polymerase sigma factor SigB -
GH761_RS04040 791132..791605 - 474 WP_003761314.1 anti-sigma B factor RsbW -
GH761_RS04045 791589..791933 - 345 WP_003721460.1 anti sigma b factor antagonist RsbV -
GH761_RS04050 792083..793087 - 1005 WP_045553450.1 PP2C family protein-serine/threonine phosphatase -
GH761_RS04055 793104..793514 - 411 WP_010990667.1 anti-sigma regulatory factor -
GH761_RS04060 793517..793873 - 357 WP_003721457.1 STAS domain-containing protein -
GH761_RS04065 793879..794715 - 837 WP_003771126.1 STAS domain-containing protein -
GH761_RS04070 794967..795314 - 348 WP_010990666.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
GH761_RS04075 795318..795596 - 279 WP_003761302.1 CopG family ribbon-helix-helix protein Antitoxin
GH761_RS04080 795802..796908 - 1107 WP_010990665.1 alanine racemase -
GH761_RS04085 796927..797283 - 357 WP_003761296.1 holo-ACP synthase -
GH761_RS04090 797285..798664 - 1380 WP_153648254.1 protoporphyrinogen oxidase -
GH761_RS04095 798815..800299 - 1485 WP_070753405.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12801.85 Da        Isoelectric Point: 6.4735

>T142466 WP_010990666.1 NZ_CP045743:c795314-794967 [Listeria innocua]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMAKVNQALEVSLGVVEF

Download         Length: 348 bp

>T142466 NZ_CP060704:3916200-3916490 [Chitinimonas koreensis]
ATGAGCTATGAGCTGGCCTTCCATCCAGCCGCGCTAGCCGAATGGCGCAGCCTGGACGGCTCGGTGCGCAAGCAGCTCAA
GACCAAGCTGGCCGAGCGGCTGGAGCAGCCCCACGTGCCGGCCGCGCGGGTCAGCGGTGGAGCCGATCTGTACAAGATCA
AGCTGCGCGCGCTCGGCTACCGGCTGGTCTACCAGGTACAGGACAGCCGCATCACGGTACTGGTATTGGCCGTCGGCCGG
CGCGACCGCAATGCCGCCTATGTGGCCGCGCTCGGCCGGATCGAGCCCTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10605.13 Da        Isoelectric Point: 4.2980

>AT142466 WP_003761302.1 NZ_CP045743:c795596-795318 [Listeria innocua]
VLEKEKRMIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVEA
EAEDRNISILGG

Download         Length: 279 bp

>AT142466 NZ_CP060704:3915959-3916210 [Chitinimonas koreensis]
ATGGAAACCATACTCGCCAACCGCTCGGTCGGCCTCAGCGAACTCAAGGCCAACCCGGCCGCCGTCATGCGTGCCGCCGA
GACCGAACCGGTCGCCATCCTCAACCGCAACAAGCCGGCCGGTTACGTGATCGGTACCGCGGCGTGGGAAGCCATCGCCG
AGCGGCTGGACAATCTGGCGCTGGCCGAGCTGGCCGCCGCCCGGCTGGCCGATGGACAGGCGCCGGTCAAGGTGACGCTG
GATGAGCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7E4N0

Antitoxin

Source ID Structure
AlphaFold DB H1GC21

References