Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2849855..2850686 Replicon chromosome
Accession NZ_CP045741
Organism Escherichia coli strain DH5alpha

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag GHR40_RS13510 Protein ID WP_000854814.1
Coordinates 2849855..2850229 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID P76364
Locus tag GHR40_RS13515 Protein ID WP_001285584.1
Coordinates 2850318..2850686 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHR40_RS13470 2845251..2846417 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
GHR40_RS13475 2846536..2847009 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
GHR40_RS13480 2847207..2848265 + 1059 WP_046613327.1 FUSC family protein -
GHR40_RS13485 2848437..2848766 + 330 WP_000450409.1 DUF496 family protein -
GHR40_RS13490 2848867..2849049 - 183 WP_001016348.1 hypothetical protein -
GHR40_RS13495 2849121..2849249 + 129 Protein_2613 transposase domain-containing protein -
GHR40_RS13500 2849538..2849651 - 114 WP_001161660.1 DUF957 domain-containing protein -
GHR40_RS13505 2849664..2849858 - 195 WP_000988600.1 hypothetical protein -
GHR40_RS13510 2849855..2850229 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
GHR40_RS13515 2850318..2850686 - 369 WP_001285584.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
GHR40_RS13520 2850760..2850981 - 222 WP_000692323.1 DUF987 domain-containing protein -
GHR40_RS13525 2851044..2851490 - 447 WP_000187523.1 RadC family protein -
GHR40_RS13530 2851487..2853019 - 1533 WP_001350525.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T142447 WP_000854814.1 NZ_CP045741:c2850229-2849855 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T142447 NZ_CP060700:c1932711-1932397 [Staphylococcus pseudintermedius]
ATGGGTAATTATTCTGTCTTAATTAAGAATTCAGCCAAAAATGACTTGAAAAAAATTAAAAAGTCACTTCTTAAAGAGCA
ATTTTCAAAAATTATTGAAGTTTTAAAGATTAACCCTTATGAAGCTAGTCAATCTTTTGAGAAGCTACAACCGAAGCATT
CAGCTCGATATTCAAGGCGTCTGAATCATCAACATAGAGTTGTGTATACGGTTGATGATGAAAAAAGAGAAGTTTATATT
TTTCTGCTTGGTCATATTATGAGTGAGCGATATGTAAATAAGTGCTGTGAAAGCATTGATAGTGAGTTATATTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13651.52 Da        Isoelectric Point: 5.9541

>AT142447 WP_001285584.1 NZ_CP045741:c2850686-2850318 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCDYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT142447 NZ_CP060700:c1932968-1932711 [Staphylococcus pseudintermedius]
ATGATTATTAAAACGCCTACAAATGCTAGAAAAGAGTTTTACGAGTTGTTAAAACAAGTTAATGATAATCATGAGCCTAT
TATAATAAGTGGTTCTAAAAGTGAAAACAATGCAGTTATTGTTAGTCAGGAAGACTGGGATAGTATTCAAGAAACGTTAT
TTCTCGAATACACTGGTACTATGGATAAAGTAAGAGCACGTGAAAAAGATGATAGTGGTTATACCAATATTGACGATATA
GATTGGGATAATTTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
PDB 2H28
AlphaFold DB A0A1M2E8G6

References