Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5694668..5695282 Replicon chromosome
Accession NZ_CP045739
Organism Pseudomonas aeruginosa strain AG1

Toxin (Protein)


Gene name hicA Uniprot ID A6VBH9
Locus tag PaeAG1_RS26980 Protein ID WP_071534354.1
Coordinates 5695100..5695282 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A140SDX7
Locus tag PaeAG1_RS26975 Protein ID WP_012077229.1
Coordinates 5694668..5695072 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PaeAG1_RS26950 5690808..5691518 + 711 WP_012074129.1 hypothetical protein -
PaeAG1_RS26955 5691515..5692435 + 921 WP_012074128.1 hypothetical protein -
PaeAG1_RS26960 5692432..5692971 + 540 WP_012074127.1 hypothetical protein -
PaeAG1_RS26965 5692971..5693669 + 699 WP_033896049.1 hypothetical protein -
PaeAG1_RS26970 5693654..5694625 + 972 WP_012077228.1 hypothetical protein -
PaeAG1_RS26975 5694668..5695072 - 405 WP_012077229.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PaeAG1_RS26980 5695100..5695282 - 183 WP_071534354.1 type II toxin-antitoxin system HicA family toxin Toxin
PaeAG1_RS26985 5695825..5696757 - 933 WP_003120918.1 ZIP family metal transporter -
PaeAG1_RS26990 5696776..5697387 - 612 WP_003098862.1 superoxide dismutase -
PaeAG1_RS26995 5697400..5697849 - 450 WP_003094369.1 hypothetical protein -
PaeAG1_RS27000 5697877..5699253 - 1377 WP_003098863.1 class II fumarate hydratase -
PaeAG1_RS27005 5699246..5699641 - 396 WP_003162782.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5657788..5695282 37494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6702.74 Da        Isoelectric Point: 10.4826

>T142427 WP_071534354.1 NZ_CP045739:c5695282-5695100 [Pseudomonas aeruginosa]
MRSREVIDLLLEDGWYEVAVKGSHHQFKHPSKPGKVTVQHPSSTIPKGTLNNILKQAGLK

Download         Length: 183 bp

>T142427 NZ_CP060678:c4037822-4037424 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14670.54 Da        Isoelectric Point: 4.4315

>AT142427 WP_012077229.1 NZ_CP045739:c5695072-5694668 [Pseudomonas aeruginosa]
MKFPVVLHKDPDSDYGVTVPDVPGCFSAGATVSEALANVEEALALHFEGLVTDGEELPQPQDVDAHMKNPDFEGGVWAVV
DFDVTPYLGKAVRFNATLPEHLLQRIDERVKVDKRYQSRSGFLATAAMRELSVA

Download         Length: 405 bp

>AT142427 NZ_CP060678:c4038049-4037822 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6VBH9

Antitoxin

Source ID Structure
AlphaFold DB A0A140SDX7

References