Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4053148..4054369 Replicon chromosome
Accession NZ_CP045739
Organism Pseudomonas aeruginosa strain AG1

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H2Z8V4
Locus tag PaeAG1_RS19055 Protein ID WP_003110488.1
Coordinates 4053791..4054369 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PaeAG1_RS19050 Protein ID WP_003088112.1
Coordinates 4053148..4053702 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PaeAG1_RS19025 4048716..4049267 + 552 WP_003450159.1 XRE family transcriptional regulator -
PaeAG1_RS19030 4049264..4049662 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
PaeAG1_RS19035 4049675..4049998 - 324 WP_015648646.1 multidrug efflux SMR transporter -
PaeAG1_RS19040 4050329..4050790 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
PaeAG1_RS19045 4050795..4052990 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
PaeAG1_RS19050 4053148..4053702 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
PaeAG1_RS19055 4053791..4054369 + 579 WP_003110488.1 HD domain-containing protein Toxin
PaeAG1_RS19060 4054478..4055665 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
PaeAG1_RS19065 4055655..4057826 - 2172 WP_025297367.1 type I secretion system permease/ATPase -
PaeAG1_RS19070 4057816..4059093 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(7-188)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21913.75 Da        Isoelectric Point: 5.3655

>T142425 WP_003110488.1 NZ_CP045739:4053791-4054369 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

>T142425 NZ_CP060678:2429891-2430046 [Salmonella enterica]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT142425 WP_003088112.1 NZ_CP045739:4053148-4053702 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT142425 NZ_CP060678:c2429879-2429821 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2Z8V4

Antitoxin

Source ID Structure

References