Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2783143..2783659 Replicon chromosome
Accession NZ_CP045739
Organism Pseudomonas aeruginosa strain AG1

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag PaeAG1_RS13460 Protein ID WP_025297453.1
Coordinates 2783378..2783659 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag PaeAG1_RS13455 Protein ID WP_025297454.1
Coordinates 2783143..2783388 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PaeAG1_RS13435 2778265..2778594 - 330 WP_031692728.1 hypothetical protein -
PaeAG1_RS13440 2778942..2779610 + 669 WP_071534660.1 hypothetical protein -
PaeAG1_RS13445 2779607..2780713 + 1107 WP_025297456.1 XRE family transcriptional regulator -
PaeAG1_RS13450 2780844..2782985 + 2142 WP_025297455.1 hypothetical protein -
PaeAG1_RS13455 2783143..2783388 + 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PaeAG1_RS13460 2783378..2783659 + 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PaeAG1_RS13465 2784065..2784646 - 582 WP_033895412.1 plasmid pRiA4b ORF-3 family protein -
PaeAG1_RS13470 2784660..2785535 - 876 WP_033895413.1 WYL domain-containing protein -
PaeAG1_RS13475 2785670..2787244 + 1575 WP_025297452.1 DNA recombination protein RmuC -
PaeAG1_RS13480 2787268..2787916 + 649 Protein_2664 peptidase M15 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2766378..2833673 67295


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T142424 WP_025297453.1 NZ_CP045739:2783378-2783659 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

>T142424 NZ_CP060678:2180423-2180526 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT142424 WP_025297454.1 NZ_CP045739:2783143-2783388 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp

>AT142424 NZ_CP060678:c2180528-2180383 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References