Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 162392..162897 Replicon chromosome
Accession NZ_CP045739
Organism Pseudomonas aeruginosa strain AG1

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag PaeAG1_RS00780 Protein ID WP_003083773.1
Coordinates 162392..162673 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PaeAG1_RS00785 Protein ID WP_003083775.1
Coordinates 162670..162897 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PaeAG1_RS00755 157643..158992 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
PaeAG1_RS00760 159041..159727 + 687 WP_003083762.1 FadR family transcriptional regulator -
PaeAG1_RS00765 159828..160562 + 735 WP_004346926.1 GntR family transcriptional regulator -
PaeAG1_RS00770 160766..161152 + 387 WP_014602345.1 aegerolysin family protein -
PaeAG1_RS00775 161184..162092 - 909 WP_003083769.1 LysR family transcriptional regulator -
PaeAG1_RS00780 162392..162673 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
PaeAG1_RS00785 162670..162897 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PaeAG1_RS00790 163073..163693 - 621 WP_003101226.1 hypothetical protein -
PaeAG1_RS00795 163794..164294 + 501 WP_003101228.1 LEA type 2 family protein -
PaeAG1_RS00800 164367..164708 + 342 WP_003101229.1 alkylphosphonate utilization protein -
PaeAG1_RS00805 164790..166217 - 1428 WP_003083784.1 GABA permease -
PaeAG1_RS00810 166386..167879 - 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T142420 WP_003083773.1 NZ_CP045739:c162673-162392 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T142420 NZ_CP060678:841484-841792 [Salmonella enterica]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT142420 WP_003083775.1 NZ_CP045739:c162897-162670 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT142420 NZ_CP060678:841242-841481 [Salmonella enterica]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References