Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2264105..2265663 Replicon chromosome
Accession NZ_CP045732
Organism Legionella sp. MW5194

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag GH742_RS10475 Protein ID WP_203454914.1
Coordinates 2264341..2265663 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GH742_RS10470 Protein ID WP_203454913.1
Coordinates 2264105..2264347 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GH742_RS10455 2260796..2262238 - 1443 WP_203454910.1 metalloprotease TldD -
GH742_RS10460 2262249..2263064 - 816 WP_203454911.1 carbon-nitrogen hydrolase family protein -
GH742_RS10465 2263242..2263919 + 678 WP_203454912.1 Bax inhibitor-1/YccA family protein -
GH742_RS10470 2264105..2264347 + 243 WP_203454913.1 helix-turn-helix domain-containing protein Antitoxin
GH742_RS10475 2264341..2265663 + 1323 WP_203454914.1 type II toxin-antitoxin system HipA family toxin Toxin
GH742_RS10480 2265665..2266633 - 969 WP_203454915.1 2-oxoacid:ferredoxin oxidoreductase subunit beta -
GH742_RS10485 2266611..2268434 - 1824 WP_203454916.1 2-oxoacid:acceptor oxidoreductase subunit alpha -
GH742_RS10490 2268421..2269167 - 747 WP_203454917.1 pyridoxine 5'-phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(8-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-61)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 50174.91 Da        Isoelectric Point: 7.7653

>T142418 WP_203454914.1 NZ_CP045732:2264341-2265663 [Legionella sp. MW5194]
MVKKNLALHVLMNGLLIGELEKTNQGALKFSYSPTWLNYPGARPLSLSLPLTEQAYRGDVVYNFFDNLLPDNQQLRTRIQ
ARFQIATNQPFDLLASIGRDCVGAIQLVSGPVPLFEKTIKYNPLSESKIASILRNYQINPLGMSREDESFRISIAGAQEK
AAFLFYNHQWCEPLQETPTTHIFKLPIGFIAHQQMDLRDSCENEWLCAQLAKAYGLPVADCDILYFEDVKVLSVTRFDRR
LSSDKRWIMRLPQEDMCQALGISNNLKYQSDGGPGIKDIMDLLLGSSHALDDRDMFFRAQIFFWLIAGIDGHAKNFSLHI
EPEGKYRLTPLYDIMSAYPLITKKQLQKQKIKMAMALKGKNNHYHWHTMQSRHFLETAHAVNYSVERAEQLLDDMLEKTD
KVIEVVSKQLPATFPATISEPILTGLHKAKQKLSNLLPTE

Download         Length: 1323 bp

>T142418 NZ_CP060678:693280-693771 [Salmonella enterica]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9324.74 Da        Isoelectric Point: 8.7136

>AT142418 WP_203454913.1 NZ_CP045732:2264105-2264347 [Legionella sp. MW5194]
MNTNELAILLRERRKKLQLTQKEMGERVGLKQKTISALENNPENASIRTLQRVLAALEMDMQLTPKNAADETKMQWDNEW

Download         Length: 243 bp

>AT142418 NZ_CP060678:692990-693283 [Salmonella enterica]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCCGAGGAAGCGCTGA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References