Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3619502..3620122 Replicon chromosome
Accession NZ_CP045726
Organism Citrobacter freundii strain zone4

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GHT30_RS17325 Protein ID WP_002892050.1
Coordinates 3619904..3620122 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag GHT30_RS17320 Protein ID WP_003021733.1
Coordinates 3619502..3619876 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHT30_RS17310 3614648..3615841 + 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GHT30_RS17315 3615864..3619013 + 3150 WP_003021736.1 multidrug efflux RND transporter permease subunit -
GHT30_RS17320 3619502..3619876 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
GHT30_RS17325 3619904..3620122 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GHT30_RS17330 3620304..3620855 + 552 WP_003835924.1 maltose O-acetyltransferase -
GHT30_RS17335 3620972..3621442 + 471 WP_119173998.1 YlaC family protein -
GHT30_RS17340 3621521..3621661 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
GHT30_RS17345 3621663..3621923 - 261 WP_003021719.1 type B 50S ribosomal protein L31 -
GHT30_RS17350 3622112..3623665 + 1554 WP_003835927.1 EAL domain-containing protein -
GHT30_RS17355 3623717..3624070 - 354 WP_003831033.1 DUF1428 family protein -
GHT30_RS17360 3624135..3624764 - 630 WP_003021707.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T142411 WP_002892050.1 NZ_CP045726:3619904-3620122 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T142411 NZ_CP060676:3755992-3756405 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT142411 WP_003021733.1 NZ_CP045726:3619502-3619876 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT142411 NZ_CP060676:3755745-3756011 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGACGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References