Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3114809..3115426 Replicon chromosome
Accession NZ_CP045720
Organism Pantoea eucalypti strain LMG 24197

Toxin (Protein)


Gene name Hha Uniprot ID E0LTU7
Locus tag EE896_RS14615 Protein ID WP_003850458.1
Coordinates 3115211..3115426 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E0LTU8
Locus tag EE896_RS14610 Protein ID WP_003850455.1
Coordinates 3114809..3115186 (+) Length 126 a.a.

Genomic Context

EE896_RS14580EE896_RS14585EE896_RS14605EE896_RS14610EE896_RS14615EE896_RS14625EE896_RS14635EE896_RS14590EE896_RS14595EE896_RS14600EE896_RS14630EE896_RS14640EE896_RS14645
Location: 3111119..3111379 (261 bp)
Type: Others
Protein ID: WP_008924911.1
Location: 3111383..3111523 (141 bp)
Type: Others
Protein ID: WP_003850445.1
Location: 3114308..3114661 (354 bp)
Type: Others
Protein ID: WP_003850454.1
Location: 3114809..3115186 (378 bp)
Type: Antitoxin
Protein ID: WP_003850455.1
Location: 3115211..3115426 (216 bp)
Type: Toxin
Protein ID: WP_003850458.1
Location: 3115846..3116163 (318 bp)
Type: Others
Protein ID: WP_039659087.1
Location: 3116942..3117805 (864 bp)
Type: Others
Protein ID: WP_003850463.1
Location: 3111569..3112447 (879 bp)
Type: Others
Protein ID: WP_003850447.1
Location: 3112463..3113302 (840 bp)
Type: Others
Protein ID: WP_003850449.1
Location: 3113299..3113967 (669 bp)
Type: Others
Protein ID: WP_008924910.1
Location: 3116194..3116751 (558 bp)
Type: Others
Protein ID: WP_008924908.1
Location: 3117855..3119141 (1287 bp)
Type: Others
Protein ID: WP_003850465.1
Location: 3119176..3119514 (339 bp)
Type: Others
Protein ID: WP_003850469.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
EE896_RS145803111119..3111379+261WP_008924911.1type B 50S ribosomal protein L31-
EE896_RS145853111383..3111523+141WP_003850445.1type B 50S ribosomal protein L36-
EE896_RS145903111569..3112447-879WP_003850447.1metal ABC transporter substrate-binding protein-
EE896_RS145953112463..3113302-840WP_003850449.1metal ABC transporter permease-
EE896_RS146003113299..3113967-669WP_008924910.1ABC transporter ATP-binding protein-
EE896_RS146053114308..3114661+354WP_003850454.1hypothetical protein-
EE896_RS146103114809..3115186+378WP_003850455.1Hha toxicity modulator TomBAntitoxin
EE896_RS146153115211..3115426+216WP_003850458.1hemolysin expression modulator HhaToxin
EE896_RS146253115846..3116163+318WP_039659087.1MGMT family protein-
EE896_RS146303116194..3116751-558WP_008924908.1YbaY family lipoprotein-
EE896_RS146353116942..3117805+864WP_003850463.1acyl-CoA thioesterase II-
EE896_RS146403117855..3119141-1287WP_003850465.1ammonium transporter AmtB-
EE896_RS146453119176..3119514-339WP_003850469.1P-II family nitrogen regulator-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8510.90 Da        Isoelectric Point: 9.4825

>T142386 WP_003850458.1 NZ_CP045720:3115211-3115426 [Pantoea eucalypti]
MNKTLTKTDYLMRLRRCRSLDTLERVIEKNKYELPEDELAVFYSAADHRLAELTMNKLYDKVPGSVWKFVR

Download         Length: 216 bp

>T142386 NZ_CP060674:1568007-1568110 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14636.25 Da        Isoelectric Point: 4.3976

>AT142386 WP_003850455.1 NZ_CP045720:3114809-3115186 [Pantoea eucalypti]
MDEYSPKRHDIAQLKYLCESLFDDSMATLTDSHHGWVNDPTSESNLQLNDLIEHIASFTMNYKIKHVEDEALISQIDEYL
DDTFMLFSNYGVNSPDLQRWQRSAKRLFNLFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT142386 NZ_CP060674:c1568112-1567967 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A1I5AGC3

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A1I5AG55

References