Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3114809..3115426 Replicon chromosome
Accession NZ_CP045720
Organism Pantoea eucalypti strain LMG 24197

Toxin (Protein)


Gene name Hha Uniprot ID E0LTU7
Locus tag EE896_RS14615 Protein ID WP_003850458.1
Coordinates 3115211..3115426 (+) Length 72 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID E0LTU8
Locus tag EE896_RS14610 Protein ID WP_003850455.1
Coordinates 3114809..3115186 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
EE896_RS14580 3111119..3111379 + 261 WP_008924911.1 type B 50S ribosomal protein L31 -
EE896_RS14585 3111383..3111523 + 141 WP_003850445.1 type B 50S ribosomal protein L36 -
EE896_RS14590 3111569..3112447 - 879 WP_003850447.1 metal ABC transporter substrate-binding protein -
EE896_RS14595 3112463..3113302 - 840 WP_003850449.1 metal ABC transporter permease -
EE896_RS14600 3113299..3113967 - 669 WP_008924910.1 ABC transporter ATP-binding protein -
EE896_RS14605 3114308..3114661 + 354 WP_003850454.1 hypothetical protein -
EE896_RS14610 3114809..3115186 + 378 WP_003850455.1 Hha toxicity modulator TomB Antitoxin
EE896_RS14615 3115211..3115426 + 216 WP_003850458.1 hemolysin expression modulator Hha Toxin
EE896_RS14625 3115846..3116163 + 318 WP_039659087.1 MGMT family protein -
EE896_RS14630 3116194..3116751 - 558 WP_008924908.1 YbaY family lipoprotein -
EE896_RS14635 3116942..3117805 + 864 WP_003850463.1 acyl-CoA thioesterase II -
EE896_RS14640 3117855..3119141 - 1287 WP_003850465.1 ammonium transporter AmtB -
EE896_RS14645 3119176..3119514 - 339 WP_003850469.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(12-68)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 72 a.a.        Molecular weight: 8510.90 Da        Isoelectric Point: 9.4825

>T142386 WP_003850458.1 NZ_CP045720:3115211-3115426 [Pantoea eucalypti]
MNKTLTKTDYLMRLRRCRSLDTLERVIEKNKYELPEDELAVFYSAADHRLAELTMNKLYDKVPGSVWKFVR

Download         Length: 216 bp

>T142386 NZ_CP060674:1568007-1568110 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 14636.25 Da        Isoelectric Point: 4.3976

>AT142386 WP_003850455.1 NZ_CP045720:3114809-3115186 [Pantoea eucalypti]
MDEYSPKRHDIAQLKYLCESLFDDSMATLTDSHHGWVNDPTSESNLQLNDLIEHIASFTMNYKIKHVEDEALISQIDEYL
DDTFMLFSNYGVNSPDLQRWQRSAKRLFNLFTEECAFLQQPSHSL

Download         Length: 378 bp

>AT142386 NZ_CP060674:c1568112-1567967 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1I5AGC3

Antitoxin

Source ID Structure
AlphaFold DB A0A1I5AG55

References