Detailed information of TA system TA142384

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2078734..2080292
• Replicon: chromosome
• Accession: NZ_CP045720
• Organism: Pantoea eucalypti strain LMG 24197

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: EE896_RS09605
• Protein ID: WP_140915597.1
• Coordinates: 2078982..2080292 (+)
• Length: 437 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: EE896_RS09600
• Protein ID: WP_003853619.1
• Coordinates: 2078734..2078982 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
EE896_RS09580	2073989..2076214	+	2226	WP_039660224.1	iron ABC transporter permease	-
EE896_RS09585	2076211..2077272	+	1062	WP_003853623.1	ABC transporter ATP-binding protein	-
EE896_RS09590	2077296..2078090	+	795	WP_105099176.1	inositol monophosphatase	-
EE896_RS09595	2078120..2078557	-	438	WP_140915598.1	GNAT family N-acetyltransferase	-
EE896_RS09600	2078734..2078982	+	249	WP_003853619.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
EE896_RS09605	2078982..2080292	+	1311	WP_140915597.1	type II toxin-antitoxin system HipA family toxin	Toxin
EE896_RS09610	2080394..2080600	+	207	WP_003853616.1	type II toxin-antitoxin system MqsA family antitoxin	-
EE896_RS09615	2080902..2082284	+	1383	WP_140915596.1	M24 family metallopeptidase	-
EE896_RS09620	2082399..2084444	+	2046	WP_140915595.1	FUSC family protein	-
EE896_RS09625	2084784..2085119	-	336	WP_105099181.1	gamma-glutamylcyclotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (148-401)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 437 a.a.
• Molecular weight: 49098.42 Da
• Isoelectric Point: 6.6643

>T142384 WP_140915597.1 NZ_CP045720:2078982-2080292 [Pantoea eucalypti]
MQRLIAWMNGERVGVLTWQRNGTHAFQYDTGWLSNPLSRPLSLSMPLQVKAITSHAVINFFDNLLPDSPLIRERIAARYQ
TQSCEPFDLLQEVGRDTVGAIMLLPPDRPLPAVQARYEVLDEARLESVLSARYDIPLGMLHEEPDFRLSVAGAQEKTALL
LTQEGWSIPAGGTSASHIIKLPVGEIKQPTATLDMRESVENEYLCLTLARALGINVPQATIIRAGKMRALAVERFDRRWS
RDKTRLIRLPQEDFCQALGLTSSTQYESDGGPGIAEIMQILMGSRHAIEDRYRFMMFQVFQWLIGATDGHARNFSLFIER
GGSYRLTPFYDVISAYPVQSGSGMNTQTLTLAMGLGATQEKRTEIDKIYPRHFIATAKQVSFDRDSLQQIFDFFIKALPQ
AIVLVRDALPPDFPQHIADAIFSHALIMLERLRHGE

Nucleotide

• Length: 1311 bp

>T142384 NZ_CP060674:c658362-658105 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9278.55 Da
• Isoelectric Point: 6.2126

>AT142384 WP_003853619.1 NZ_CP045720:2078734-2078982 [Pantoea eucalypti]
MIYSPIQLANQLKFIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQALEVSLAVQEKEAVTATHLHDED
EW

Nucleotide

• Length: 249 bp

>AT142384 NZ_CP060674:658187-658519 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT