142383

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 361542..363367 Replicon chromosome
Accession NZ_CP045719
Organism Vibrio cholerae O395 substr. TCP2

Toxin (Protein)


Gene name hipA Uniprot ID A0A0K9UVP8
Locus tag GG844_RS07135 Protein ID WP_000392003.1
Coordinates 362006..363367 (-) Length 454 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GG844_RS07130 Protein ID WP_000804849.1
Coordinates 361542..362009 (-) Length 156 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GG844_RS07115 356822..357526 - 705 WP_001880605.1 NERD domain-containing protein -
GG844_RS07120 357596..360532 - 2937 WP_001283873.1 DEAD/DEAH box helicase family protein -
GG844_RS07125 360536..361114 - 579 WP_000109982.1 class I SAM-dependent methyltransferase -
GG844_RS07130 361542..362009 - 468 WP_000804849.1 helix-turn-helix domain-containing protein Antitoxin
GG844_RS07135 362006..363367 - 1362 WP_000392003.1 type II toxin-antitoxin system HipA family toxin Toxin
GG844_RS07145 363971..364948 + 978 WP_001889101.1 IS481-like element ISVch1 family transposase -
GG844_RS07150 364974..365654 - 681 Protein_311 IS5 family transposase -
GG844_RS07155 365996..367516 - 1521 WP_000640055.1 aldehyde dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(166-383)

Antitoxin

(80-138)


Sequences


Toxin        


Download         Length: 454 a.a.        Molecular weight: 51246.17 Da        Isoelectric Point: 4.9109

>T142383 WP_000392003.1 NZ_CP045719:c363367-362006 [Vibrio cholerae O395]
MEELTVQAFIRGEWIDIGIISFPKSSQHNFRVTELNYLSDYALEHYDKDDFHAVSLNHPVSFIFDDMGKPGWLKFLDDIM
PSGASRRYWVKHLDIEDLSSDEQDYVLLKFGTMSPIGNLRIKDSLPERYEVADNLYFSVDDVKNRAGDFLDYAQQRGAAA
GGATGAGGEAPKLILRCGFDHGSGSEKIWIDPYQDDNSSHDLHYLVKYPRGSRSTIDCNILRAEFYFYHELTEMGVETIS
TDGMRLEEGLNYPSLWLPRFDVQIIDQQIERFGMESVYSILNKGAGVTLDHETTIRTLIEKITESNMVKHQGYRFDTQAF
VIEWVKRDLLNILFGNSDNHGRNTSFLKGDGVIKLAPIYDFAPMKADPAGIPRTTKWKAPLEVGGTYDFVGIADTLSDLV
PKEMLLKELAITASKCVGLKQRLALRGVPEQILEMPAVGLNYLSEKLTKWGLL

Download         Length: 1362 bp

>T142383 NZ_CP060674:273069-273356 [Salmonella enterica]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17095.51 Da        Isoelectric Point: 10.6157

>AT142383 WP_000804849.1 NZ_CP045719:c362009-361542 [Vibrio cholerae O395]
MKPSNKESVQDTVARLRENRNQQQSKVGKNATHSSKEQTPLDTPTRSKASKNAKAVSAAERKTEANKIIKHLLLGELTQG
QALKSLRINILGLKQDVFARLVDVSRKTLSDIENDRGSYNTEILNKVFKPFSLKIGLLPSSPDALKSLLMDGEDG

Download         Length: 468 bp

>AT142383 NZ_CP060674:273343-273645 [Salmonella enterica]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0K9UVP8


Antitoxin

Source ID Structure

References