Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-Phd
Location 912235..912813 Replicon chromosome
Accession NZ_CP045718
Organism Vibrio cholerae O395 substr. TCP2

Toxin (Protein)


Gene name parE Uniprot ID O68848
Locus tag GG844_RS04545 Protein ID WP_001180243.1
Coordinates 912496..912813 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q7DCR7
Locus tag GG844_RS04540 Protein ID WP_000557292.1
Coordinates 912235..912477 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GG844_RS04490 907660..907698 - 39 WP_106019119.1 hypothetical protein -
GG844_RS04495 907714..907839 - 126 WP_001944767.1 DUF645 family protein -
GG844_RS19685 908016..908126 - 111 WP_134814058.1 DUF3265 domain-containing protein -
GG844_RS04505 908123..908440 - 318 WP_001232701.1 HigA family addiction module antidote protein -
GG844_RS04510 908451..908738 - 288 WP_001162670.1 type II toxin-antitoxin system RelE/ParE family toxin -
GG844_RS04515 909005..909185 - 181 Protein_863 DUF645 family protein -
GG844_RS04520 909610..909843 - 234 WP_032482776.1 DUF3709 domain-containing protein -
GG844_RS04525 910246..910464 - 219 WP_001917086.1 DUF3709 domain-containing protein -
GG844_RS04530 910774..911427 - 654 WP_000226874.1 hypothetical protein -
GG844_RS04535 911484..911993 - 510 WP_000405986.1 GNAT family N-acetyltransferase -
GG844_RS04540 912235..912477 + 243 WP_000557292.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GG844_RS04545 912496..912813 + 318 WP_001180243.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GG844_RS19690 913007..913102 - 96 WP_012706049.1 DUF645 family protein -
GG844_RS04555 913561..914523 + 963 WP_000841995.1 integron integrase IntIA -
GG844_RS04560 914605..914958 - 354 WP_001138366.1 50S ribosomal protein L20 -
GG844_RS04565 915000..915194 - 195 WP_001885060.1 50S ribosomal protein L35 -
GG844_RS04570 915298..915849 - 552 WP_001894072.1 translation initiation factor IF-3 -
GG844_RS04575 915853..917781 - 1929 WP_001121783.1 threonine--tRNA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 833007..914523 81516


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-93)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12158.97 Da        Isoelectric Point: 9.7495

>T142382 WP_001180243.1 NZ_CP045718:912496-912813 [Vibrio cholerae O395]
MQNKQYKLSQLAQEHLLKIKHYTIENFAEAQWQKYKSTLLSGFQTLADNPGLGKSCEDIYQNGFYFPVGKHMAYYTKEAN
FILIVAVLGQSQLPQKHLKQSRFVS

Download         Length: 318 bp

>T142382 NZ_CP060674:229076-229384 [Salmonella enterica]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.25 Da        Isoelectric Point: 5.6630

>AT142382 WP_000557292.1 NZ_CP045718:912235-912477 [Vibrio cholerae O395]
MHTLTANDAKRNFGELLLSAQREPVIISKNSKNTVVVMSIKDFEELEAMKLDYLKHCFESAQKDLDSGKTVDGATFLNTL

Download         Length: 243 bp

>AT142382 NZ_CP060674:228834-229073 [Salmonella enterica]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9UJR8

Antitoxin

Source ID Structure
AlphaFold DB Q7DCR7

References