Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /GNAT-DUF1778 |
| Location | 900108..900874 | Replicon | chromosome |
| Accession | NZ_CP045718 | ||
| Organism | Vibrio cholerae O395 substr. TCP2 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | Q9K2P7 |
| Locus tag | GG844_RS04430 | Protein ID | WP_000982260.1 |
| Coordinates | 900377..900874 (+) | Length | 166 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | Q9K2J6 |
| Locus tag | GG844_RS04425 | Protein ID | WP_000246253.1 |
| Coordinates | 900108..900380 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GG844_RS04370 | 895357..895983 | - | 627 | WP_000365423.1 | LysE family translocator | - |
| GG844_RS04375 | 896025..896117 | - | 93 | WP_014378730.1 | DUF3265 domain-containing protein | - |
| GG844_RS04380 | 896132..896605 | - | 474 | WP_001161076.1 | GrpB family protein | - |
| GG844_RS04385 | 896805..896987 | - | 183 | WP_000923182.1 | DUF645 family protein | - |
| GG844_RS04390 | 897155..897277 | - | 123 | WP_086027501.1 | DUF3265 domain-containing protein | - |
| GG844_RS04395 | 897804..897983 | - | 180 | WP_001889214.1 | DUF645 family protein | - |
| GG844_RS04400 | 898412..898735 | - | 324 | WP_001889156.1 | DUF3709 domain-containing protein | - |
| GG844_RS04410 | 898927..899322 | - | 396 | WP_000870841.1 | DUF3465 domain-containing protein | - |
| GG844_RS04420 | 899536..899718 | - | 183 | WP_000947517.1 | DUF645 family protein | - |
| GG844_RS04425 | 900108..900380 | + | 273 | WP_000246253.1 | DUF1778 domain-containing protein | Antitoxin |
| GG844_RS04430 | 900377..900874 | + | 498 | WP_000982260.1 | GNAT family N-acetyltransferase | Toxin |
| GG844_RS04440 | 901077..901247 | - | 171 | WP_000483445.1 | DUF645 family protein | - |
| GG844_RS04450 | 902033..902467 | - | 435 | WP_000453957.1 | GNAT family N-acetyltransferase | - |
| GG844_RS04455 | 902618..903031 | - | 414 | WP_000049417.1 | VOC family protein | - |
| GG844_RS19680 | 903063..903158 | - | 96 | WP_080368267.1 | acetyltransferase | - |
| GG844_RS04460 | 903215..903670 | - | 456 | WP_001245327.1 | GNAT family N-acetyltransferase | - |
| GG844_RS04465 | 903800..904675 | - | 876 | WP_000259044.1 | hypothetical protein | - |
| GG844_RS04475 | 905122..905604 | - | 483 | WP_001895003.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 833007..914523 | 81516 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 166 a.a. Molecular weight: 18527.18 Da Isoelectric Point: 8.7753
>T142380 WP_000982260.1 NZ_CP045718:900377-900874 [Vibrio cholerae O395]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG
Download Length: 498 bp
>T142380 NZ_CP045718:900377-900874 [Vibrio cholerae O395]
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG
ATGATGAATACGGTACTTCTCGATAAAGATAAGCACGATAGGAACCGTTTCAATTGTGGCACTGAAGCACTCAACAATTA
CTTAAAAGTAATGGCGAGTCAGCAAGCCAAAAAAGACAACACCAGAACCTTCGTTTTGGAAGATGACAATAACAGTGCTT
ATATCATCGGCTTTTACACTCTGACTATGACGCCCATTGATTTGAAAGCCTTGCCCGACAAGTTACAAAAGAAGCACCAA
TCCTCAACCTCTGGAGGGCTCATTGCTCGTTTAGCTGTCGACGATAGATACAAAGGAAAAGGTTTTGGTGAGTGGCTACT
CATTGACGCTCTCAGAAAGCTACTCGCAGCCAGTGACAGTGTAGCGTTCCCTGTTGTCATTGTTGATGCCAAAGATGGTG
CAAAACATTTCTATGAGCGCTATGGGTTTCAAGCGTTTCAAGATGCCGAAAACAAACTCTTCATCACCATTGCTGATATC
AGAGCAAGCTTAGGCTAG
Antitoxin
Download Length: 91 a.a. Molecular weight: 9683.22 Da Isoelectric Point: 6.2988
>AT142380 WP_000246253.1 NZ_CP045718:900108-900380 [Vibrio cholerae O395]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ
Download Length: 273 bp
>AT142380 NZ_CP045718:900108-900380 [Vibrio cholerae O395]
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA
ATGGCAACGACTTTGCCTCGCATCACCGCTAGAGTTGATGTCGATACTCAAGATTTACTCGCTAAGGCTGCTGCTCTTGC
TGGTATGTCTAGTATTAACTCATTTGTTTTGAATGCAGCAATCGAAAAAGCAAAACAAGTCATTGAACGTGAGCAAGCTC
TAAAGCTTAGCCAAGCTGATGCCGTATTGCTGATGGAAGCTCTTGATAATCCAGCTGTAGTAAATGCAAAGCTCAAATTG
GCATCCGAACGTTATGAGAGCAAAACTCAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0Q0KGB1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 1Y9B | |
| AlphaFold DB | A0A0F2IC79 |