142379

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 892385..892923 Replicon chromosome
Accession NZ_CP045718
Organism Vibrio cholerae O395 substr. TCP2

Toxin (Protein)


Gene name parE Uniprot ID Q9KMJ0
Locus tag GG844_RS04340 Protein ID WP_000802136.1
Coordinates 892624..892923 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P58093
Locus tag GG844_RS04335 Protein ID WP_001107719.1
Coordinates 892385..892627 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GG844_RS04290 887801..887941 - 141 WP_001883049.1 DUF3265 domain-containing protein -
GG844_RS04295 887907..888842 - 936 WP_000051985.1 restriction endonuclease -
GG844_RS04300 889123..889722 - 600 WP_000429495.1 hypothetical protein -
GG844_RS04305 889877..890143 - 267 WP_000937852.1 hypothetical protein -
GG844_RS04310 890357..891040 - 684 WP_000877436.1 hypothetical protein -
GG844_RS04320 891464..891556 - 93 WP_014164112.1 DUF3265 domain-containing protein -
GG844_RS04325 891578..892156 - 579 WP_000110120.1 hypothetical protein -
GG844_RS04335 892385..892627 + 243 WP_001107719.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
GG844_RS04340 892624..892923 + 300 WP_000802136.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GG844_RS04345 893051..893446 - 396 WP_000870857.1 DUF3465 domain-containing protein -
GG844_RS04350 893660..893839 - 180 WP_001883058.1 DUF645 family protein -
GG844_RS04360 894416..894526 - 111 WP_079857360.1 DUF3265 domain-containing protein -
GG844_RS04365 894536..895234 - 699 WP_001890502.1 hypothetical protein -
GG844_RS04370 895357..895983 - 627 WP_000365423.1 LysE family translocator -
GG844_RS04375 896025..896117 - 93 WP_014378730.1 DUF3265 domain-containing protein -
GG844_RS04380 896132..896605 - 474 WP_001161076.1 GrpB family protein -
GG844_RS04385 896805..896987 - 183 WP_000923182.1 DUF645 family protein -
GG844_RS04390 897155..897277 - 123 WP_086027501.1 DUF3265 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 833007..914523 81516


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(1-79)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11589.29 Da        Isoelectric Point: 9.9232

>T142379 WP_000802136.1 NZ_CP045718:892624-892923 [Vibrio cholerae O395]
MKPFNLTVAAKADLRDIALFTQRRWGKEQRNVYLKQFDDSFWLLAENPDIGKSCDEIREGYRKFPQGSHVIFYQQTGSQQ
IRVIRILHKSMDVNPIFGA

Download         Length: 300 bp

>T142379 NZ_CP060673:44889-46214 [Salmonella enterica]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8964.84 Da        Isoelectric Point: 4.1677

>AT142379 WP_001107719.1 NZ_CP045718:892385-892627 [Vibrio cholerae O395]
MAKNTSITLGEHFDGFITSQIQSGRYGSASEVIRSALRLLENQETKLQSLRQLLIEGEQSGDADYDLDSFINELDSENIR

Download         Length: 243 bp

>AT142379 NZ_CP060673:44591-44884 [Salmonella enterica]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7R5A

Antitoxin

Source ID Structure
AlphaFold DB A0A151JFU4

References