Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-YafN |
| Location | 873415..873980 | Replicon | chromosome |
| Accession | NZ_CP045718 | ||
| Organism | Vibrio cholerae O395 substr. TCP2 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | D7HCW8 |
| Locus tag | GG844_RS04160 | Protein ID | WP_000869999.1 |
| Coordinates | 873415..873702 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | D0IIK3 |
| Locus tag | GG844_RS04165 | Protein ID | WP_000086649.1 |
| Coordinates | 873699..873980 (-) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GG844_RS04120 | 868671..868907 | - | 237 | WP_001065132.1 | hypothetical protein | - |
| GG844_RS04125 | 869151..869576 | - | 426 | WP_000403003.1 | GNAT family N-acetyltransferase | - |
| GG844_RS04130 | 869671..870081 | - | 411 | WP_000452031.1 | hypothetical protein | - |
| GG844_RS04135 | 870196..870756 | - | 561 | Protein_796 | hypothetical protein | - |
| GG844_RS04140 | 870756..871448 | - | 693 | WP_000780703.1 | hypothetical protein | - |
| GG844_RS04145 | 871656..871838 | - | 183 | WP_001889223.1 | DUF645 family protein | - |
| GG844_RS04150 | 872133..872582 | - | 450 | WP_000480555.1 | hypothetical protein | - |
| GG844_RS04155 | 872717..873256 | - | 540 | WP_000884561.1 | hydrolase | - |
| GG844_RS04160 | 873415..873702 | - | 288 | WP_000869999.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GG844_RS04165 | 873699..873980 | - | 282 | WP_000086649.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GG844_RS04175 | 874194..874619 | - | 426 | WP_000735184.1 | hypothetical protein | - |
| GG844_RS04180 | 874769..874855 | - | 87 | WP_071917830.1 | DUF3265 domain-containing protein | - |
| GG844_RS04185 | 874855..875217 | - | 363 | WP_000454151.1 | hypothetical protein | - |
| GG844_RS04190 | 875368..875826 | - | 459 | WP_000650937.1 | hypothetical protein | - |
| GG844_RS04195 | 876035..876217 | - | 183 | WP_000947513.1 | DUF645 family protein | - |
| GG844_RS04200 | 876520..877035 | - | 516 | WP_001201533.1 | lipocalin family protein | - |
| GG844_RS04205 | 877062..877211 | - | 150 | WP_071908333.1 | DUF3265 domain-containing protein | - |
| GG844_RS04210 | 877184..877435 | - | 252 | WP_001890111.1 | TIGR03643 family protein | - |
| GG844_RS04215 | 877630..877833 | - | 204 | WP_001911580.1 | hypothetical protein | - |
| GG844_RS04220 | 878090..878476 | - | 387 | WP_000703163.1 | VOC family protein | - |
| GG844_RS04225 | 878515..878625 | - | 111 | Protein_813 | DUF3265 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 833007..914523 | 81516 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 10997.74 Da Isoelectric Point: 6.0710
>T142378 WP_000869999.1 NZ_CP045718:c873702-873415 [Vibrio cholerae O395]
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
MKVVWSPLALQKLGDAAEFIALDNPSAAEKWVNEVFDKTELLGSMPEMGRMVPEMPHTNYREIIFGHYRIIYSLSHEIRV
LTVRNCRQLLTEHDV
Download Length: 288 bp
>T142378 NZ_CP060673:17701-18006 [Salmonella enterica]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10361.93 Da Isoelectric Point: 5.1548
>AT142378 WP_000086649.1 NZ_CP045718:c873980-873699 [Vibrio cholerae O395]
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
MSRIHLDQDIQPLSEFRAGVASFIKQINETRRPLVITQRGKGVAVVLDVAEYEAMQEKIELLEEMRTAEAQLAAGLGISN
EDARSQVLGRIIK
Download Length: 282 bp
>AT142378 NZ_CP060673:17481-17699 [Salmonella enterica]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3AEF1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0K9UIW4 |