Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-Phd |
| Location | 867518..868065 | Replicon | chromosome |
| Accession | NZ_CP045718 | ||
| Organism | Vibrio cholerae O395 substr. TCP2 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0H3AD26 |
| Locus tag | GG844_RS04105 | Protein ID | WP_000807826.1 |
| Coordinates | 867518..867820 (-) | Length | 101 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | Q9KM93 |
| Locus tag | GG844_RS04110 | Protein ID | WP_000861987.1 |
| Coordinates | 867808..868065 (-) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GG844_RS04055 | 862793..863188 | - | 396 | WP_000870868.1 | DUF3465 domain-containing protein | - |
| GG844_RS04060 | 863474..863797 | - | 324 | WP_001999495.1 | DUF3709 domain-containing protein | - |
| GG844_RS04065 | 863981..864367 | - | 387 | WP_001015083.1 | MmcQ/YjbR family DNA-binding protein | - |
| GG844_RS04070 | 864507..865433 | - | 927 | WP_000377815.1 | hypothetical protein | - |
| GG844_RS04075 | 865582..865944 | - | 363 | WP_002034853.1 | hypothetical protein | - |
| GG844_RS04085 | 866284..866505 | - | 222 | WP_032074688.1 | DUF3709 domain-containing protein | - |
| GG844_RS04090 | 866526..866678 | - | 153 | Protein_788 | DUF3709 domain-containing protein | - |
| GG844_RS04095 | 866668..866784 | - | 117 | WP_114732087.1 | DUF3265 domain-containing protein | - |
| GG844_RS04100 | 866775..867356 | - | 582 | WP_001025027.1 | hypothetical protein | - |
| GG844_RS04105 | 867518..867820 | - | 303 | WP_000807826.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| GG844_RS04110 | 867808..868065 | - | 258 | WP_000861987.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| GG844_RS04120 | 868671..868907 | - | 237 | WP_001065132.1 | hypothetical protein | - |
| GG844_RS04125 | 869151..869576 | - | 426 | WP_000403003.1 | GNAT family N-acetyltransferase | - |
| GG844_RS04130 | 869671..870081 | - | 411 | WP_000452031.1 | hypothetical protein | - |
| GG844_RS04135 | 870196..870756 | - | 561 | Protein_796 | hypothetical protein | - |
| GG844_RS04140 | 870756..871448 | - | 693 | WP_000780703.1 | hypothetical protein | - |
| GG844_RS04145 | 871656..871838 | - | 183 | WP_001889223.1 | DUF645 family protein | - |
| GG844_RS04150 | 872133..872582 | - | 450 | WP_000480555.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integron | - | - | 833007..914523 | 81516 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 101 a.a. Molecular weight: 11725.65 Da Isoelectric Point: 5.1972
>T142377 WP_000807826.1 NZ_CP045718:c867820-867518 [Vibrio cholerae O395]
MAEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPLELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
MAEIIWTEPALSDLNDIAEYIALENVVAAKQLVQTVFTKVERLADFPESGRVPLELEHLNYREVVVNPCRVFYKYDDAKV
RILFVMRAERDLRRLMLTKQ
Download Length: 303 bp
>T142377 NZ_CP060672:c4675761-4675276 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG
Antitoxin
Download Length: 86 a.a. Molecular weight: 9647.15 Da Isoelectric Point: 7.3178
>AT142377 WP_000861987.1 NZ_CP045718:c868065-867808 [Vibrio cholerae O395]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLIDVDDYEFMQNRLAILEGIARGERALADGKVVSHQDAKDRM
SKWLK
Download Length: 258 bp
>AT142377 NZ_CP060672:c4676036-4675749 [Salmonella enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3AD26 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1T4SLM9 |