Detailed information of TA system TA142376

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 852381..852909
• Replicon: chromosome
• Accession: NZ_CP045718
• Organism: Vibrio cholerae O395 substr. TCP2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: H9L4R3
• Locus tag: GG844_RS03955
• Protein ID: WP_000221352.1
• Coordinates: 852619..852909 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: H9L4T4
• Locus tag: GG844_RS03950
• Protein ID: WP_000213183.1
• Coordinates: 852381..852629 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GG844_RS03905	847421..847885	+	465	WP_000140244.1	hypothetical protein	-
GG844_RS03910	847985..848383	-	399	WP_001882293.1	hypothetical protein	-
GG844_RS03915	848539..849039	-	501	WP_000789723.1	hypothetical protein	-
GG844_RS03920	849177..849707	-	531	WP_000415562.1	hypothetical protein	-
GG844_RS03925	849858..850253	-	396	WP_000649527.1	DUF3465 domain-containing protein	-
GG844_RS03930	850461..850886	-	426	WP_000415748.1	hypothetical protein	-
GG844_RS03935	851157..851810	-	654	WP_000036957.1	site-specific DNA-methyltransferase	-
GG844_RS03950	852381..852629	+	249	WP_000213183.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GG844_RS03955	852619..852909	+	291	WP_000221352.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GG844_RS03960	853045..853560	-	516	WP_001201531.1	lipocalin family protein	-
GG844_RS03965	853697..854173	-	477	WP_001047171.1	GNAT family N-acetyltransferase	-
GG844_RS03970	854201..854311	-	111	WP_071917832.1	DUF3265 domain-containing protein	-
GG844_RS03975	854308..855237	-	930	WP_000335802.1	hypothetical protein	-
GG844_RS03980	855357..855803	-	447	WP_000128977.1	hypothetical protein	-
GG844_RS03985	855955..856959	-	1005	WP_000964934.1	LD-carboxypeptidase	-
GG844_RS19665	857172..857210	-	39	WP_106019119.1	hypothetical protein	-
GG844_RS19670	857226..857351	-	126	WP_001944767.1	DUF645 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	833007..914523	81516

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11247.23 Da
• Isoelectric Point: 10.4678

>T142376 WP_000221352.1 NZ_CP045718:852619-852909 [Vibrio cholerae O395]
MTYKLEFKKSALKEWKKLAVPLQQQFKKKLIERLENPHVPSAKLSGAENIYKIKLRQSGYRLVYQVENDIIVVTVLAVGK
RERSEVYTKALQRLDD

Nucleotide

• Length: 291 bp

>T142376 NZ_CP060672:c4565689-4565321 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTGGGCATATCTTCAATGATGGTAACAAACGTACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGTCGTTCGCTTACGCGCCTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8937.28 Da
• Isoelectric Point: 4.1079

>AT142376 WP_000213183.1 NZ_CP045718:852381-852629 [Vibrio cholerae O395]
MTTRILADVAASITEFKANPMKVATSAFGAPVAVLNRNEPAFYCVPASTYEIMMDKLEDLELLAIAKERLSEDSVSVNID
DL

Nucleotide

• Length: 249 bp

>AT142376 NZ_CP060672:c4565907-4565686 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGAGCTGGCGGATAAATGA

Structures

Toxin

• AlphaFold DB: H9L4R3

Antitoxin

• AlphaFold DB: A0A366A3W8