142372

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /GNAT-DUF1778
Location 812709..813475 Replicon chromosome
Accession NZ_CP045718
Organism Vibrio cholerae O395 substr. TCP2

Toxin (Protein)


Gene name - Uniprot ID Q9K2P7
Locus tag GG844_RS03650 Protein ID WP_000982260.1
Coordinates 812978..813475 (+) Length 166 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q9K2J6
Locus tag GG844_RS03645 Protein ID WP_000246253.1
Coordinates 812709..812981 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GG844_RS03600 807937..808854 - 918 WP_000186333.1 alpha/beta hydrolase -
GG844_RS03605 809088..809390 - 303 WP_000229317.1 type II toxin-antitoxin system RelE/ParE family toxin -
GG844_RS03610 809378..809635 - 258 WP_000861987.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GG844_RS03620 809837..810370 - 534 WP_000118351.1 GNAT family N-acetyltransferase -
GG844_RS19640 810367..810792 - 426 WP_001882332.1 DUF1778 domain-containing protein -
GG844_RS03630 810859..811230 - 372 WP_001164080.1 nucleotide pyrophosphohydrolase -
GG844_RS03635 811371..811658 - 288 WP_000426470.1 hypothetical protein -
GG844_RS03640 811810..812478 - 669 WP_000043871.1 hypothetical protein -
GG844_RS03645 812709..812981 + 273 WP_000246253.1 DUF1778 domain-containing protein Antitoxin
GG844_RS03650 812978..813475 + 498 WP_000982260.1 GNAT family N-acetyltransferase Toxin
GG844_RS03655 813772..814266 + 495 WP_000477435.1 hypothetical protein -
GG844_RS03660 814584..816242 + 1659 WP_001125478.1 recombinase family protein -
GG844_RS03665 816729..817130 - 402 WP_012706059.1 hypothetical protein -
GG844_RS03670 817145..817522 - 378 WP_000073388.1 hypothetical protein -
GG844_RS03675 817539..817814 - 276 WP_000095573.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 791552..816242 24690
- inside Integron - - 799407..812981 13574


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(86-152)

Antitoxin

Vibrio phage ICP1, Orf50

(7-86)


Sequences

Toxin        


Download         Length: 166 a.a.        Molecular weight: 18527.18 Da        Isoelectric Point: 8.7753

>T142372 WP_000982260.1 NZ_CP045718:812978-813475 [Vibrio cholerae O395]
MMNTVLLDKDKHDRNRFNCGTEALNNYLKVMASQQAKKDNTRTFVLEDDNNSAYIIGFYTLTMTPIDLKALPDKLQKKHQ
SSTSGGLIARLAVDDRYKGKGFGEWLLIDALRKLLAASDSVAFPVVIVDAKDGAKHFYERYGFQAFQDAENKLFITIADI
RASLG

Download         Length: 498 bp

>T142372 NZ_CP060672:3886377-3886904 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9683.22 Da        Isoelectric Point: 6.2988

>AT142372 WP_000246253.1 NZ_CP045718:812709-812981 [Vibrio cholerae O395]
MATTLPRITARVDVDTQDLLAKAAALAGMSSINSFVLNAAIEKAKQVIEREQALKLSQADAVLLMEALDNPAVVNAKLKL
ASERYESKTQ

Download         Length: 273 bp

>AT142372 NZ_CP060672:3886090-3886380 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Q0KGB1

Antitoxin

Source ID Structure
PDB 1Y9B
AlphaFold DB A0A0F2IC79

References