Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 23275..23810 Replicon plasmid pFHI_NMBU_11_02
Accession NZ_CP045714
Organism Escherichia coli strain FHI_NMBU_11

Toxin (Protein)


Gene name relE Uniprot ID A0A085NW92
Locus tag GHT02_RS26500 Protein ID WP_001563269.1
Coordinates 23523..23810 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A085NW91
Locus tag GHT02_RS26495 Protein ID WP_001563268.1
Coordinates 23275..23526 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHT02_RS26465 18649..18873 + 225 WP_000493532.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
GHT02_RS26470 18870..19256 + 387 WP_000673981.1 type II toxin-antitoxin system death-on-curing family toxin -
GHT02_RS26475 19619..20260 + 642 WP_001473476.1 recombinase family protein -
GHT02_RS26480 20793..21218 - 426 WP_001563264.1 nucleoside triphosphatase NudI -
GHT02_RS26485 21220..21927 - 708 WP_001563265.1 deoxynucleoside kinase -
GHT02_RS26490 21924..22790 - 867 WP_064562334.1 radical SAM protein -
GHT02_RS26495 23275..23526 + 252 WP_001563268.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GHT02_RS26500 23523..23810 + 288 WP_001563269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GHT02_RS26505 23978..24382 + 405 WP_001563270.1 DUF2251 domain-containing protein -
GHT02_RS26510 24691..26175 + 1485 WP_001563271.1 alpha/beta hydrolase -
GHT02_RS26515 26396..27004 - 609 WP_044783647.1 proQ/FINO family protein -
GHT02_RS26520 27282..27643 + 362 Protein_38 hypothetical protein -
GHT02_RS26525 27612..27815 - 204 WP_171973489.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..108688 108688
- flank IS/Tn - - 19619..20260 641


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.43 Da        Isoelectric Point: 10.6698

>T142361 WP_001563269.1 NZ_CP045714:23523-23810 [Escherichia coli]
MTYTIKFRDDALKEWLKLDKTIQQQFVKKLKKCSKNPHILSAKLRGLKDCYKIKLRASGFRLVYQVIDDMLIIAVVAVGK
RERSNVYYLASERMR

Download         Length: 288 bp

>T142361 NZ_CP060671:c76657-75332 [Salmonella enterica]
ATGAGCCGGAAACAGCAACGTCTGGTAATTTGGATGAACGGCATCAAAGTCGGGTACTGGGAAAAAAGCAAAGGGGTAGA
CAGCTTAGAATACCTTCCTGAATGGGTTGCTGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTGCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTGCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACTGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGAGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGGCCAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAGACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCGTTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAGGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAATTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCAAACTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9140.34 Da        Isoelectric Point: 4.0780

>AT142361 WP_001563268.1 NZ_CP045714:23275-23526 [Escherichia coli]
MPNIILSDISASVSELKKNPMATVGAGDGYPVAILNRNQPAFYCVPAELYERMLDALDDQELVKLVTERSSQPLHDVDLD
SYS

Download         Length: 252 bp

>AT142361 NZ_CP060671:c76955-76662 [Salmonella enterica]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGCTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGCGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCCATCCTGGGCGTAAAAATCAGCTTCTCCTCGGCAACCACCTCTTCAGAGAGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085NW92

Antitoxin

Source ID Structure
AlphaFold DB A0A085NW91

References