Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4743654..4744485 Replicon chromosome
Accession NZ_CP045712
Organism Escherichia coli strain FHI_NMBU_11

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag GHT02_RS22895 Protein ID WP_000854814.1
Coordinates 4743654..4744028 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag GHT02_RS22900 Protein ID WP_001285585.1
Coordinates 4744117..4744485 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GHT02_RS22855 4739050..4740216 + 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
GHT02_RS22860 4740335..4740808 + 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
GHT02_RS22865 4741006..4742064 + 1059 WP_001200891.1 FUSC family protein -
GHT02_RS22870 4742236..4742565 + 330 WP_000450409.1 DUF496 family protein -
GHT02_RS22875 4742666..4742848 - 183 WP_001016348.1 hypothetical protein -
GHT02_RS22880 4742920..4743048 + 129 Protein_4465 transposase domain-containing protein -
GHT02_RS22885 4743337..4743450 - 114 WP_001161660.1 DUF957 domain-containing protein -
GHT02_RS22890 4743463..4743657 - 195 WP_000988600.1 hypothetical protein -
GHT02_RS22895 4743654..4744028 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
GHT02_RS22900 4744117..4744485 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
GHT02_RS22905 4744559..4744780 - 222 WP_000692323.1 DUF987 domain-containing protein -
GHT02_RS22910 4744843..4745319 - 477 WP_001186773.1 RadC family protein -
GHT02_RS22915 4745335..4745814 - 480 WP_000860074.1 antirestriction protein -
GHT02_RS22920 4745896..4746714 - 819 WP_001234629.1 DUF945 domain-containing protein -
GHT02_RS22925 4746814..4747047 - 234 WP_001119729.1 DUF905 family protein -
GHT02_RS22930 4747126..4747581 - 456 WP_000581504.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T142348 WP_000854814.1 NZ_CP045712:c4744028-4743654 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T142348 NZ_CP060670:2942066-2942593 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT142348 WP_001285585.1 NZ_CP045712:c4744485-4744117 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT142348 NZ_CP060670:2941779-2942069 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References