Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | itaRT/DUF1778(antitoxin) |
| Location | 1394007..1394844 | Replicon | chromosome |
| Accession | NZ_CP045712 | ||
| Organism | Escherichia coli strain FHI_NMBU_11 | ||
Toxin (Protein)
| Gene name | itaT | Uniprot ID | Q3Z4X7 |
| Locus tag | GHT02_RS06955 | Protein ID | WP_000227784.1 |
| Coordinates | 1394302..1394844 (+) | Length | 181 a.a. |
Antitoxin (Protein)
| Gene name | itaR | Uniprot ID | I2UQS9 |
| Locus tag | GHT02_RS06950 | Protein ID | WP_001297137.1 |
| Coordinates | 1394007..1394318 (+) | Length | 104 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GHT02_RS06925 | 1389027..1389974 | + | 948 | WP_001239441.1 | cytochrome o ubiquinol oxidase subunit II | - |
| GHT02_RS06930 | 1389996..1391987 | + | 1992 | WP_000467180.1 | cytochrome o ubiquinol oxidase subunit I | - |
| GHT02_RS06935 | 1391977..1392591 | + | 615 | WP_000179819.1 | cytochrome o ubiquinol oxidase subunit III | - |
| GHT02_RS06940 | 1392591..1392920 | + | 330 | WP_000019869.1 | cytochrome o ubiquinol oxidase subunit IV | - |
| GHT02_RS06945 | 1392932..1393822 | + | 891 | WP_000971340.1 | heme o synthase | - |
| GHT02_RS06950 | 1394007..1394318 | + | 312 | WP_001297137.1 | DUF1778 domain-containing protein | Antitoxin |
| GHT02_RS06955 | 1394302..1394844 | + | 543 | WP_000227784.1 | GNAT family N-acetyltransferase | Toxin |
| GHT02_RS06960 | 1394900..1395835 | - | 936 | WP_001371638.1 | sel1 repeat family protein | - |
| GHT02_RS06965 | 1396243..1397607 | + | 1365 | WP_001000959.1 | MFS transporter | - |
| GHT02_RS06970 | 1397735..1398226 | - | 492 | WP_001138904.1 | nucleotide binding protein YajQ | - |
| GHT02_RS06975 | 1398394..1399305 | + | 912 | WP_000705836.1 | 2-dehydropantoate 2-reductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 181 a.a. Molecular weight: 19805.02 Da Isoelectric Point: 8.3395
>T142335 WP_000227784.1 NZ_CP045712:1394302-1394844 [Escherichia coli]
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA
MVDKHEEITLPIVLSCNYQSDITYPGQKQFDCGNPVIDKFVRASLKKSVRNSDCAAKALIDRQSGELIGICTFTAYSLEK
QRVSGVLQGSQPSEIGVVRLVMLGVARKYQKRGFGQDLLCDFFEHVKIIHQALPIKGVYLDADPAAINFYARLGFVQLSA
TPNAFGAVPMFLAIQHILAA
Download Length: 543 bp
>T142335 NZ_CP060668:c3037681-3037578 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 104 a.a. Molecular weight: 11358.04 Da Isoelectric Point: 10.4825
>AT142335 WP_001297137.1 NZ_CP045712:1394007-1394318 [Escherichia coli]
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA
MPGKTATLPDVDKTLKNARVELKTSPDAKNKLREAAQAVGVDLSAFILSAAMERAESVLDNQRRRELSNQSWELMNQLIA
EPAQPTLALKALMKRKNSDGRQA
Download Length: 312 bp
>AT142335 NZ_CP060668:3037576-3037721 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|