Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
Location | 493152..493789 | Replicon | chromosome |
Accession | NZ_CP045711 | ||
Organism | Bacillus velezensis strain HN-Q-8 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | G4NU33 |
Locus tag | GG619_RS02510 | Protein ID | WP_003156187.1 |
Coordinates | 493439..493789 (+) | Length | 117 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | I2HMS5 |
Locus tag | GG619_RS02505 | Protein ID | WP_003156188.1 |
Coordinates | 493152..493433 (+) | Length | 94 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GG619_RS02485 | 489517..490116 | - | 600 | WP_003156193.1 | rhomboid family intramembrane serine protease | - |
GG619_RS02490 | 490209..490574 | + | 366 | WP_007410229.1 | holo-ACP synthase | - |
GG619_RS02495 | 490739..491746 | + | 1008 | WP_007410230.1 | outer membrane lipoprotein carrier protein LolA | - |
GG619_RS02500 | 491863..493032 | + | 1170 | WP_061890435.1 | alanine racemase | - |
GG619_RS02505 | 493152..493433 | + | 282 | WP_003156188.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
GG619_RS02510 | 493439..493789 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
GG619_RS02515 | 493907..494728 | + | 822 | WP_015416874.1 | STAS domain-containing protein | - |
GG619_RS02520 | 494733..495098 | + | 366 | WP_003156180.1 | RsbT antagonist protein RsbS | - |
GG619_RS02525 | 495101..495502 | + | 402 | WP_003156178.1 | anti-sigma regulatory factor | - |
GG619_RS02530 | 495514..496521 | + | 1008 | WP_015416875.1 | PP2C family protein-serine/threonine phosphatase | - |
GG619_RS02535 | 496585..496914 | + | 330 | WP_033575044.1 | anti-sigma factor antagonist | - |
GG619_RS02540 | 496911..497393 | + | 483 | WP_007609591.1 | anti-sigma B factor RsbW | - |
GG619_RS02545 | 497359..498147 | + | 789 | WP_003156171.1 | RNA polymerase sigma factor SigB | - |
GG619_RS02550 | 498147..498749 | + | 603 | WP_007410234.1 | SpoIIE family protein phosphatase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T142330 WP_003156187.1 NZ_CP045711:493439-493789 [Bacillus velezensis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T142330 NZ_CP060668:704811-705086 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA
Antitoxin
Download Length: 94 a.a. Molecular weight: 10562.92 Da Isoelectric Point: 6.4706
>AT142330 WP_003156188.1 NZ_CP045711:493152-493433 [Bacillus velezensis]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHYAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT142330 NZ_CP060668:704548-704808 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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